Treatments and drugs
By Mayo Clinic staffTreatment of dementia may help slow or minimize the development of symptoms.
- Cholinesterase inhibitors. These drugs — donepezil (Aricept), rivastigmine (Exelon) and galantamine hydrobromide (Razadyne) — are Alzheimer's drugs that work by boosting levels of a chemical messenger involved in memory and judgment. Side effects can include nausea, vomiting and diarrhea. Although primarily used as Alzheimer's drugs, they're also used to treat vascular, Parkinson's and Lewy body dementias.
- Memantine (Namenda). This drug for Alzheimer's disease works by regulating the activity of glutamate, another chemical messenger involved in all brain function, including learning and memory. Its most common side effect is dizziness. Some research has shown that combining memantine with a cholinesterase inhibitor may have even better results. Although primarily used to treat Alzheimer's disease, it may help improve symptoms in other dementias.
- Other medications. Although no standard treatment for dementia exists, some symptoms can be treated. Additional treatments aim to reduce the risk factors for further brain damage.
Treatment of the underlying causes of dementia can also slow or sometimes stop its progress. To prevent a stroke, for example, your doctor may prescribe medications to control high blood pressure, high cholesterol, heart disease and diabetes. Doctors may also prescribe medication to treat conditions such as blood clots, anxiety and insomnia for people with vascular dementia.
In addition, some specific symptoms and behavioral problems can be treated with sedatives, antidepressants and other medications, but some of these drugs may worsen other symptoms.
Creutzfeldt-Jakob disease has no known treatments. Care is focused on making sure the person is comfortable.
- Dementia: Hope through research. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/dementias/detail_dementia.htm#1318919213. Accessed Jan. 25, 2010.
- Dementia. Alzheimer's Association. http://www.alz.org/alzheimers_disease_dementia.asp. Accessed Jan. 25, 2011.
- Alternative treatments. Alzheimer's Association. http://www.alz.org/alzheimers_disease_alternative_treatments.asp. Accessed Jan. 25, 2011.
- A guide to dementia diagnosis and treatment. The American Geriatrics Society. http://www.americangeriatrics.org/press/listservs/december_10_2010427672/id:1442 Accessed Jan. 25, 2011.
- NIH State-of-the-science conference statement on preventing Alzheimer's disease and cognitive decline. National Institutes of Health. http://consensus.nih.gov/2010/docs/alz/alz_stmt.pdf. Accessed Jan. 7, 2011.
- Ritchie K, et al. Designing prevention programmes to reduce incidence of dementia: Prospective cohort study of modifiable risk factors. British Medical Journal. 2010;341:c3885.
- Rusanen M, et al. Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia. Archives of Internal Medicine. In press. Accessed Jan. 25, 2011.
- Siedlecki KL, et al. Comparison of patient and caregiver reports of patient activity participation and its relationship to mental health in patients with Alzheimer's disease. Journal of Gerontology: Psychological Services. 2009;64B:687.
- Scarmeas N, et al. Physical activity, diet, and risk of Alzheimer's disease. Journal of the American Medical Association. 2009;302:627.

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