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Causes
By Mayo Clinic staffDengue fever is caused by any one of four dengue viruses spread by the Aedes aegypti mosquito. These mosquitoes thrive in and near human habitations, where they breed in even the cleanest water.
Mosquitoes transmit the virus back and forth between humans. When a mosquito bites a person infected with a dengue virus, the virus enters the mosquito's bloodstream. It then circulates before settling in the salivary glands. When the infected mosquito then bites another person, the virus enters that person's bloodstream, where it may cause the serious illness.
You can become infected with dengue fever more than once. This happens when you're exposed to a different one of the four dengue viruses from the one to which you were previously exposed. Infection a second time is typically what causes the more severe form of the disease — dengue hemorrhagic fever.
- Dengue fever overview. National Institute of Allergy and Infectious Diseases. http://www3.niaid.nih.gov/topics/DengueFever/Understanding/overview.htm. Accessed Aug. 12, 2009.
- Rothman AL. Epidemiology of dengue virus infections. http://www.uptodate.com/home/index.html. Accessed Aug. 12, 2009.
- Centers for Disease Control and Prevention, et al. Dengue hemorrhagic fever - U.S.-Mexico border, 2005. MMWR. 2007;56:31. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5631a1.htm. Accessed Aug. 12, 2009.
- Rothman AL. Clinical presentation and diagnosis of dengue virus infections. http://www.uptodate.com/home/index.html. Accessed Aug. 12, 2009.
- Rothman AL. Prevention and treatment of dengue virus infection. http://www.uptodate.com/home/index.html. Accessed Aug. 12, 2009.
- Dengue and dengue haemorrhagic fever. World Health Organization. http://www.who.int/mediacentre/factsheets/fs117/en/print.html. Accessed Aug. 12, 2009.
- Zielinski-Gutierrez E, et al. Protection against mosquitoes, ticks, and other insects and arthropods. In: Brunette GW, et al. CDC Health Information for International Travel 2010. Atlanta, Ga.: U.S. Department of Health and Human Services, Public Health Service; 2009. http://wwwn.cdc.gov/travel/yellowbook/2010/chapter-2/protection-against-mosquitoes-ticks-insects-arthropods.aspx. Accessed Aug. 17, 2009.
- West Nile virus questions and answers: Insect repellent use and safety. Centers for Disease Control and Prevention. http://www.cdc.gov/ncidod/dvbid/westnile/qa/insect_repellent.htm. Accessed Aug. 17, 2009.
- Tsai T, et al. Flaviviruses (yellow fever, dengue, dengue hemorrhagic fever, Japanese encephalitis, West Nile encephalitis, St. Louis encephalitis, tick-borne encephalitis). In: Mandell GL, et al. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 6th ed. Philadelphia, Pa.: Elsevier Churchill Livingstone; 2005. http://www.mdconsult.com/das/book/body/154687162-3/0/1259/1219.html?tocnode=51380756&fromURL=1219.html#4-u1.0-B0-443-06643-4..50152-5_5152. Accessed Aug. 17, 2009.
