DefinitionBy Mayo Clinic staff
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Depo-Provera is a well-known brand name for medroxyprogesterone acetate, a contraceptive injection for women that contains the hormone progestin. Depo-Provera is given as an injection once every three months. Depo-Provera typically suppresses ovulation, keeping your ovaries from releasing an egg. Depo-Provera also thickens cervical mucus to keep sperm from reaching the egg.
Medroxyprogesterone acetate is also available in a lower dosage. This version is called Depo-subQ Provera 104. While Depo-Provera is injected deep into the muscle, Depo-subQ Provera 104 is injected just beneath the skin. Depo-Provera and Depo-subQ Provera 104 have similar benefits and risks. However, less long-term information is available about the effectiveness of Depo-subQ Provera 104.
To use Depo-Provera or Depo-subQ Provera 104, you'll need a prescription from your doctor or other health care provider.
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