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  • With Mayo Clinic endocrinologist

    Maria Collazo-Clavell, M.D.

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Mayo Clinic Health Manager

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Question

Diabetes and depression: What's the link?

What's the connection between diabetes and depression? Can diabetes cause depression?

Answer

from Maria Collazo-Clavell, M.D.

If you have diabetes, you have an increased risk of developing depression. And if you have depression, you have a greater chance of developing type 2 diabetes. Though the relationship between diabetes and depression isn't fully understood:

  • The rigors of managing diabetes can be stressful and lead to symptoms of depression.
  • Diabetes can cause complications and health problems, such as diabetic neuropathy, that may worsen symptoms of depression.
  • Depression can lead to poor lifestyle decisions, such as unhealthy eating, less exercise, smoking and weight gain — all of which are risk factors for diabetes.
  • Depression affects your ability to perform tasks, communicate and think clearly. This can interfere with your ability to successfully manage diabetes.

The good news is that diabetes and depression can be treated together. Medications and lifestyle changes, including regular exercise, can improve both diabetes and depression.

If you have diabetes, watch for signs and symptoms of depression. These include:

  • Loss of interest in normal daily activities
  • Feeling sad, down or hopeless
  • Problems sleeping
  • Trouble focusing or concentrating
  • Difficulty making decisions
  • Unintentional weight gain or loss
  • Feeling fatigued or weak
  • Thoughts of suicide or suicidal behavior
  • Unexplained physical problems, such as back pain or headaches

If you think you may be depressed, seek help right away. Your doctor or diabetes educator can refer you to a mental health professional.

Next question
Diabetes: How does it affect my liver?
References
  1. Golden SH, et al. Examining a bidirectional association between depressive symptoms and diabetes. Journal of the American Medical Association. 2008;299:2751.
  2. Depression. American Diabetes Association. https://www.diabetes.org/type-2-diabetes/depression.jsp. Accessed June 30, 2009.
  3. Petrak F, et al. Treatment of depression in diabetes: An update. Current Opinion in Psychiatry. 2009;22:211.
  4. Lyness JM. Depression: Clinical manifestations and diagnosis. http://www.uptodate.com/home/index.html. Accessed June 30, 2009.
  5. What I need to know about physical activity and diabetes. National Institute of Diabetes and Digestive and Kidney Diseases. http://diabetes.niddk.nih.gov/dm/pubs/physical_ez/physactivity.pdf. Accessed July 1, 2009.
  6. Mead GE, et al. Exercise for depression. Cochrane Database of Systematic Reviews. 2008:CD004366.

AN02011

Sept. 24, 2009

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