Diabetes insipidus

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Complications

By Mayo Clinic staff

Dehydration
Except for dipsogenic DI, which causes you to retain too much water, diabetes insipidus can cause your body to retain too little water to function properly, and you can become dehydrated. Dehydration can cause:

  • Dry mouth
  • Muscle weakness
  • Low blood pressure (hypotension)
  • Elevated blood sodium (hypernatremia)
  • Sunken appearance to your eyes
  • Fever
  • Headache
  • Rapid heart rate
  • Weight loss

Electrolyte imbalance
Diabetes insipidus can also cause an electrolyte imbalance. Electrolytes are minerals in your blood — such as sodium, potassium and calcium — that maintain the balance of fluids in your body. Electrolyte imbalance can cause symptoms, such as:

  • Headache
  • Fatigue
  • Irritability
  • Muscle pains

Water intoxication
Excessive fluid intake in dipsogenic diabetes insipidus can lead to water intoxication, a condition that lowers sodium concentration in your blood, which can damage your brain.

References
  1. What is diabetes insipidus? Diabetes Insipidus Foundation. http://www.diabetesinsipidus.org. Accessed June 18, 2010.
  2. Diabetes insipidus. National Institute of Diabetes and Digestive and Kidney Diseases. http://kidney.niddk.nih.gov/kudiseases/pubs/insipidus. Accessed June 18, 2020.
  3. Bichet DG. Diagnosis of polyuria and diabetes insipidus. http://www.uptodate.com/home/index.html. Accessed June 15, 2010.
  4. Bichet DG. Treatment of nephrogenic diabetes insipidus. http://www.uptodate.com/home/index.html. Accessed June 15, 2010.
  5. Rose BD, et al. Treatment of central diabetes insipidus. http://www.uptodate.com/home/index.html. Accessed June 15, 2010.
DS00799 Sept. 2, 2010

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