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Risk factors
By Mayo Clinic staffIt isn't clear what causes diffuse idiopathic skeletal hyperostosis, but doctors have some idea of what can increase your risk of the condition. Risk factors include:
- Certain medications. Long-term use of medications called retinoids, such as isotretinoin (Accutane, others), that are similar to vitamin A can increase your risk of diffuse idiopathic skeletal hyperostosis. It isn't clear whether high intake of vitamin A increases your risk, however.
- Sex. Men are much more likely than women are to develop diffuse idiopathic skeletal hyperostosis.
- Older age. Diffuse idiopathic skeletal hyperostosis is most common in older adults, especially in people older than 50.
- Diabetes and other conditions. People with diabetes may be more likely to develop diffuse idiopathic skeletal hyperostosis than are those who don't have diabetes. Other conditions that may raise insulin levels in your body may also increase your risk, including hyperinsulinemia, prediabetes and obesity.
