Causes
By Mayo Clinic staffDisorganized schizophrenia and other forms of schizophrenia are brain disorders. Genetics and environment likely both play a role.
Problems with certain naturally occurring brain chemicals called neurotransmitters may contribute to disorganized schizophrenia. Imaging studies show differences in the brain structure of people with schizophrenia, but the significance of these changes is unclear.
- Schizophrenia. In: Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR. 4th ed. Arlington, Va.: American Psychiatric Association; 2000. http://www.psychiatryonline.com. Accessed Sept. 29, 2010.
- Skodol AE, et al. Specific personality disorders. In: Hales RE, et al. The American Psychiatric Publishing Textbook of Psychiatry. 5th ed. Washington, D.C.: American Psychiatric Association; 2008. http://www.psychiatryonline.com/resourceToc.aspx?resourceID=5. Accessed Sept. 29, 2010.
- Jibson MD. Schizophrenia: Clinical presentation, epidemiology, and pathophysiology. http://www.uptodate.com/home/index.html. Accessed Sept. 29, 2010.
- Gejman PV, et al. The role of genetics in the etiology of schizophrenia. Psychiatric Clinics of North America. 2010;33:3.
- Schizophrenia. National Institute of Mental Health. http://www.nimh.nih.gov/health/publications/schizophrenia/complete-publication.shtml. Accessed Sept. 29, 2010.
- Jibson MD. Schizophrenia: Diagnostic evaluation and treatment. http://www.uptodate.com/home/index.html. Accessed Sept. 29, 2010.
- Families and schizophrenia: The view from advocacy. Psychiatric Clinics of North America. 2007;30:549.
- Rathod SR, et al. Cognitive behavioral therapy for schizophrenia. Psychiatric Clinics of North America. 2010;33:3.
- Staying well when you have a mental health condition. Mental Health America. http://www.nmha.org/go/mental-health-month/staying-well-when-you-have-a-mental-illness. Accessed Sept. 29, 2010.
- Hall-Flavin DK (expert opinion). Mayo Clinic, Rochester, Minn. Nov. 16, 2010.


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