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Before Using
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of candesartan and hydrochlorothiazide combination in children with use in other age groups.
Geriatric
This medicine has been tested in patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults.
Pregnancy
| Pregnancy Category | Explanation | |
|---|---|---|
| 1st Trimester | C | Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. |
| 2nd Trimester | D | Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. |
| 3rd Trimester | D | Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. |
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Dofetilide
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acetyldigoxin
- Arsenic Trioxide
- Deslanoside
- Digitalis
- Digitoxin
- Digoxin
- Droperidol
- Flecainide
- Ketanserin
- Levomethadyl
- Lithium
- Metildigoxin
- Ouabain
- Proscillaridin
- Sotalol
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aceclofenac
- Acemetacin
- Alacepril
- Alclofenac
- Apazone
- Benazepril
- Benoxaprofen
- Bepridil
- Bromfenac
- Bufexamac
- Calcium Carbonate
- Captopril
- Carbamazepine
- Carprofen
- Celecoxib
- Chlorpropamide
- Cholestyramine
- Cilazapril
- Clometacin
- Clonixin
- Cyclophosphamide
- Delapril
- Dexketoprofen
- Diclofenac
- Diflunisal
- Dipyrone
- Droxicam
- Enalaprilat
- Enalapril Maleate
- Etodolac
- Etofenamate
- Felbinac
- Fenbufen
- Fenoprofen
- Fentiazac
- Floctafenine
- Flufenamic Acid
- Flurbiprofen
- Fosinopril
- Ginkgo
- Glipizide
- Gossypol
- Ibuprofen
- Imidapril
- Indomethacin
- Indoprofen
- Isoxicam
- Ketoprofen
- Ketorolac
- Licorice
- Lisinopril
- Lornoxicam
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Moexipril
- Nabumetone
- Naproxen
- Niflumic Acid
- Nimesulide
- Oxaprozin
- Oxyphenbutazone
- Pentopril
- Perindopril
- Phenylbutazone
- Pirazolac
- Piroxicam
- Pirprofen
- Propyphenazone
- Proquazone
- Quinapril
- Ramipril
- Rofecoxib
- Spirapril
- Sulindac
- Suprofen
- Temocapril
- Tenidap
- Tenoxicam
- Tiaprofenic Acid
- Ticrynafen
- Tolmetin
- Topiramate
- Trandolapril
- Valdecoxib
- Zofenopril
- Zomepirac
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Allergy or
- Asthma, bronchial—May have an increased risk of allergic reaction to hydrochlorothiazide
- Congestive heart failure, severe—Lowering of blood pressure by candesartan and hydrochlorothiazide combination may make this condition worse
- Diabetes mellitus— Insulin dosage may need to be adjusted.
- Fluid or electrolyte (e.g., potassium, chloride, sodium) imbalance (due to excessive perspiration, vomiting, diarrhea, etc.)—The side effects of candesartan and hydrochlorothiazide may be increased
- Kidney disease or
- Liver disease—These conditions may be aggravated by candesartan and hydrochlorothiazide
- Sympathectomy—Blood pressure-lowering effects may be increased
- Systemic lupus erythematosus—Candesartan and hydrochlorothiazide combination may trigger or worsen this condition.
