Amifostine (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Blurred vision
• Confusion
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• Fainting or loss of consciousness
• Fast or irregular breathing
• Itching
• Nausea and vomiting
• Red, scaly, swollen, or peeling areas of the skin
• Skin rash
• Sweating
• Swelling of the eyes or eyelids
• Tightness in the chest
• Trouble with breathing
• Unusual tiredness or weakness
• Wheezing

• Abdominal cramps
• Blistering, peeling, or loosening of the skin
• Burning or tingling sensation
• Chills
• Convulsions
• Cough
• Cracks in the skin
• Diarrhea
• Difficulty in breathing
• Fast, slow, or irregular heartbeat or pulse
• Fever
• Joint or muscle pain
• Loss of bladder control
• Loss of heat from the body
• Muscle cramps in the hands, arms, feet, legs, or face
• Muscle spasm or jerking of all extremities
• No blood pressure or pulse
• Numbness and tingling around the mouth, fingertips, or feet
• Palpitations
• Red irritated eyes
• Red skin lesions, often with a purple center
• Shortness of breath
• Sore throat
• Sores, ulcers, or white spots in the mouth or on the lips
• Stopping of the heart
• Sudden loss of consciousness
• Tremor
• Unconsciousness

• Difficulty in swallowing
• Hives or welts
• Hoarseness
• Slow or irregular breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Feeling unusually warm or cold
• Flushing or redness of the face or neck
• Headache
• Hiccups
• Nervousness
• Pounding in the ears
• Sleepiness (severe)
• Sneezing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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