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Before Using
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies performed to date have not demonstrated any benefit to using chlordiazepoxide and amitriptyline combination in children with depression. Studies have shown that some children, teenagers, and young adults think about suicide or attempt suicide when taking the medicine. Because of this toxicity, use in children is not recommended .
Geriatric
Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of chlordiazepoxide and amitriptyline combination in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment in the dose for patients receiving chlordiazepoxide and amitriptyline combination .
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Bepridil
- Cisapride
- Clorgyline
- Furazolidone
- Grepafloxacin
- Iproniazid
- Isocarboxazid
- Levomethadyl
- Linezolid
- Mesoridazine
- Metoclopramide
- Moclobemide
- Nialamide
- Pargyline
- Phenelzine
- Pimozide
- Procarbazine
- Selegiline
- Sparfloxacin
- Terfenadine
- Thioridazine
- Toloxatone
- Tranylcypromine
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acecainide
- Ajmaline
- Alfentanil
- Amiodarone
- Amisulpride
- Amobarbital
- Amprenavir
- Anileridine
- Aprindine
- Aprobarbital
- Arsenic Trioxide
- Astemizole
- Atazanavir
- Azimilide
- Bretylium
- Butabarbital
- Butalbital
- Carisoprodol
- Chloral Hydrate
- Chloroquine
- Chlorzoxazone
- Clarithromycin
- Clonidine
- Codeine
- Dantrolene
- Disopyramide
- Dofetilide
- Dolasetron
- Droperidol
- Enflurane
- Epinephrine
- Erythromycin
- Ethchlorvynol
- Etilefrine
- Fentanyl
- Flecainide
- Fluconazole
- Fluoxetine
- Foscarnet
- Fospropofol
- Gatifloxacin
- Gemifloxacin
- Halofantrine
- Haloperidol
- Halothane
- Hydrocodone
- Hydromorphone
- Hydroquinidine
- Ibutilide
- Isoflurane
- Isradipine
- Levorphanol
- Lidoflazine
- Lorcainide
- Lumefantrine
- Meperidine
- Mephenesin
- Mephobarbital
- Meprobamate
- Metaxalone
- Methocarbamol
- Methohexital
- Methoxamine
- Midodrine
- Morphine
- Morphine Sulfate Liposome
- Moxifloxacin
- Nefazodone
- Nefopam
- Norepinephrine
- Octreotide
- Oxilofrine
- Oxycodone
- Oxymorphone
- Pentamidine
- Pentobarbital
- Phenobarbital
- Phenylephrine
- Pirmenol
- Prajmaline
- Primidone
- Procainamide
- Prochlorperazine
- Propafenone
- Propoxyphene
- Quetiapine
- Quinidine
- Rasagiline
- Remifentanil
- Risperidone
- Secobarbital
- Sematilide
- Sertindole
- Sertraline
- Sodium Oxybate
- Sotalol
- Spiramycin
- Sufentanil
- Sulfamethoxazole
- Sultopride
- Tapentadol
- Tedisamil
- Telithromycin
- Thiopental
- Tramadol
- Trifluoperazine
- Trimethoprim
- Vasopressin
- Venlafaxine
- Ziprasidone
- Zolmitriptan
- Zotepine
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acenocoumarol
- Arbutamine
- Atomoxetine
- Bethanidine
- Carbamazepine
- Cimetidine
- Cinacalcet
- Diazepam
- Dicumarol
- Fluvoxamine
- Galantamine
- Guanethidine
- Ketoconazole
- Paroxetine
- Phenprocoumon
- Phenytoin
- Rifapentine
- Ritonavir
- S-Adenosylmethionine
- St John's Wort
- Theophylline
- Topiramate
- Warfarin
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
- Ethanol
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Alcohol abuse (or history of) or
- Drug abuse or dependence (or history of)—Dependence on this medicine may develop.
- Bipolar disorder (manic-depressive illness) or
- Blood problems or
- Difficulty in urinating or
- Emphysema, asthma, bronchitis, or other chronic lung disease or
- Enlarged prostate or
- Glaucoma or increased eye pressure or
- Heart disease or
- Mental illness (severe) or
- Myasthenia gravis or
- Porphyria—Chlordiazepoxide and amitriptyline combination may make the condition worse.
- Epilepsy or history of seizures—The risk of seizures may be increased.
- Heart attack, recent—Should not be used in patients with this condition .
- Hyperactivity—Chlordiazepoxide and amitriptyline combination may cause unexpected effects.
- Kidney disease or
- Liver disease—Higher blood levels of chlordiazepoxide and amitriptyline may occur, increasing the chance of side effects.
- Overactive thyroid or
- Stomach or intestinal problems—Use of this combination medicine may result in more serious problems.
