Diclofenac and Misoprostol (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Black, tarry stools
• Bleeding or crusting sores on the lips
• Blood in the urine or stools
• Bruises or red spots on the skin
• Chest pain
• Chills
• Confusion
• Continuing thirst
• Convulsions (seizures)
• Cough or hoarseness
• Disorientation
• Drowsiness
• Fainting
• Fever with or without chills
• Fluid retention
• General feeling of illness
• Heartburn or indigestion
• Increased blood pressure
• Increased heart rate
• Increased weight gain
• Irregular heartbeat
• Itching of the skin
• Large, flat, blue or purplish patches on the skin
• Lightheadedness or dizziness
• Lower back or side pain
• Mental depression
• Muscle cramps
• Nausea
• Painful or difficult urination
• Pounding heartbeat
• Psychotic reaction
• Rectal bleeding
• Seeing, hearing, or feeling things that are not there
• Severe headache
• Severe liver reactions
• Severe stomach pain, cramping, or burning
• Shortness of breath, troubled breathing, tightness in the chest, or wheezing
• Skin rash
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Stiff neck or back
• Sudden decrease in the amount of urine
• Swelling or tenderness in the upper stomach
• Swelling of the face, fingers, feet, or lower legs
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Vomiting of material that looks like coffee grounds
• Yellow eyes or skin

• Changes in facial skin color
• Fast or irregular breathing
• Puffiness or swelling of the eyelids or around the eyes

Get emergency help immediately if any of the following symptoms of overdose occur:

• Diarrhea
• Fever
• Slow heartbeat
• Stomach pain
• Trembling or shaking

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Gas

• Abnormal vision
• Acne
• Change in sense of taste
• Decreased appetite
• Decrease in sexual ability
• Dry mouth
• Irritability or nervousness
• Loss of hair
• Muscle pain
• Tingling, burning, or prickling sensations
• Trouble with swallowing
• Vaginal bleeding

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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