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Before Using
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of ibuprofen and oxycodone combination in children below 14 years of age. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of oxycodone and ibuprofen combination in the elderly. However, elderly patients who may be more sensitive than younger adults to the effects of ibuprofen and oxycodone combination, are more likely to have kidney, lung, or stomach problems, which may require caution in patients receiving oxycodone and ibuprofen combination.
Pregnancy
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | C | Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. |
Breastfeeding
Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.
Drug Interactions
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Ketorolac
- Naltrexone
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Adinazolam
- Alfentanil
- Alprazolam
- Amobarbital
- Anileridine
- Aprobarbital
- Ardeparin
- Beta Glucan
- Brofaromine
- Bromazepam
- Brotizolam
- Buprenorphine
- Butabarbital
- Butalbital
- Butorphanol
- Carisoprodol
- Certoparin
- Chloral Hydrate
- Chlordiazepoxide
- Chlorpromazine
- Chlorzoxazone
- Clobazam
- Clonazepam
- Clorazepate
- Clorgyline
- Codeine
- Dalteparin
- Danaparoid
- Dantrolene
- Dezocine
- Diazepam
- Enoxaparin
- Escitalopram
- Estazolam
- Ethchlorvynol
- Fentanyl
- Flunitrazepam
- Fluphenazine
- Flurazepam
- Fluvoxamine
- Fospropofol
- Furazolidone
- Ginkgo
- Halazepam
- Hydrocodone
- Hydromorphone
- Iproniazid
- Isocarboxazid
- Ketazolam
- Lazabemide
- Levorphanol
- Linezolid
- Lorazepam
- Lormetazepam
- Medazepam
- Meperidine
- Mephenesin
- Mephobarbital
- Meprobamate
- Metaxalone
- Methocarbamol
- Methohexital
- Methotrexate
- Midazolam
- Moclobemide
- Morphine
- Morphine Sulfate Liposome
- Nadroparin
- Nalbuphine
- Nialamide
- Nitrazepam
- Nordazepam
- Opium
- Oxazepam
- Oxycodone
- Oxymorphone
- Pargyline
- Parnaparin
- Pemetrexed
- Pentazocine
- Pentobarbital
- Perphenazine
- Phenelzine
- Phenobarbital
- Prazepam
- Procarbazine
- Prochlorperazine
- Promazine
- Promethazine
- Propoxyphene
- Quazepam
- Rasagiline
- Remifentanil
- Reviparin
- Secobarbital
- Selegiline
- Sertraline
- Sodium Oxybate
- Sufentanil
- Tacrolimus
- Tapentadol
- Temazepam
- Thiethylperazine
- Thiopental
- Thioridazine
- Tinzaparin
- Toloxatone
- Tranylcypromine
- Triazolam
- Trifluoperazine
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acetohexamide
- Alacepril
- Amikacin
- Amiloride
- Aspirin
- Azosemide
- Bemetizide
- Benazepril
- Bendroflumethiazide
- Benzthiazide
- Bumetanide
- Buthiazide
- Candesartan Cilexetil
- Canrenoate
- Captopril
- Chlorothiazide
- Chlorpropamide
- Chlorthalidone
- Cilazapril
- Citalopram
- Clopamide
- Clopidogrel
- Clovoxamine
- Cyclopenthiazide
- Cyclosporine
- Cyclothiazide
- Delapril
- Desipramine
- Desvenlafaxine
- Duloxetine
- Enalaprilat
- Enalapril Maleate
- Eprosartan
- Escitalopram
- Ethacrynic Acid
- Femoxetine
- Flesinoxan
- Fluoxetine
- Fluvoxamine
- Fosinopril
- Furosemide
- Gliclazide
- Glimepiride
- Glipizide
- Gliquidone
- Glyburide
- Hydrochlorothiazide
- Hydroflumethiazide
- Imidapril
- Indapamide
- Irbesartan
- Lisinopril
- Lithium
- Losartan
- Methyclothiazide
- Metolazone
- Milnacipran
- Moexipril
- Nefazodone
- Olmesartan Medoxomil
- Paroxetine
- Pentopril
- Perindopril
- Phenytoin
- Piretanide
- Polythiazide
- Quinapril
- Quinethazone
- Ramipril
- Rifampin
- Sertraline
- Spirapril
- Spironolactone
- Tacrine
- Tasosartan
- Telmisartan
- Temocapril
- Tolazamide
- Tolbutamide
- Torsemide
- Trandolapril
- Triamterene
- Trichlormethiazide
- Valsartan
- Venlafaxine
- Voriconazole
- Xipamide
- Zimeldine
- Zofenopril
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Addison's disease (adrenal gland problem) or
- Alcohol abuse, history of or
- Brain disease or
- Depression or
- Enlarged prostate (BPH, prostatic hypertrophy) or
- Head injury or
- Hypothyroidism (underactive thyroid) or
- Kidney disease, severe or
- Kyphoscoliosis (curvature of spine that can cause breathing problems) or
- Liver disease, severe or
- Lung disease, severe or
- Problems with urination or
- Psychosis (mental illness) or
- Seizure disorders or
- Systemic lupus erythematosus (SLE) or
- Weakened physical condition—Use with caution. May increase risk for more serious side effects.
- Anemia or
- Breathing problems (e.g., asthma, hypercapnia, hypoxia) or
- Bleeding problems or
- Dehydration or
- Edema (fluid retention) or
- Heart attack, history of or
- Heart disease (e.g., congestive heart failure) or
- Hypertension (high blood pressure) or
- Hypotension (low blood pressure) or
- Kidney disease or
- Liver disease or
- Lung disease (e.g., chronic obstructive pulmonary disease [COPD], cor pulmonale) or
- Pancreatitis (inflammation of the pancreas) or
- Shock or
- Stomach ulcers or bleeding, history of or
- Stroke, history of—Use with caution. May make these conditions worse.
- Aspirin-sensitive asthma or
- Aspirin sensitivity, history of or
- Bronchial asthma, acute or severe, or other chronic lung disease or
- Hypercarbia (large amount of carbon dioxide in the blood) or
- Paralytic ileus (bowel blockage) or
- Respiratory depression (troubled breathing)—Should not be used in patients with these conditions.
- Drug abuse or dependence, or history of—Dependence may be more likely to develop.
- Heart surgery (e.g., coronary artery bypass graft [CABG])—Should not be used to relieve pain right before or after the surgery.
