Arsenic Trioxide (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Chills
• Convulsions (seizures)
• Cough
• Decreased urine output
• Dry mouth
• Eye pain
• General feeling of illness
• Headache
• Increased thirst
• Irregular heartbeat
• Loss of appetite
• Mood changes
• Muscle pain or cramps
• Nausea or vomiting
• Numbness or tingling in hands, feet, or lips
• Shortness of breath or trouble breathing
• Sore throat
• Unusual tiredness or weakness

• Abdominal or stomach cramps
• Black, tarry stools
• Bluish lips or skin
• Blurred vision
• Chest pain
• Dizziness or lightheadedness
• Fever
• Flushed, dry skin
• Fruit-like breath odor
• High or low blood pressure
• Increased hunger
• Increased urine output
• Irregular or pounding heartbeat or pulse
• Painful or difficult urination
• Sores, ulcers, or white spots on lips or in mouth
• Stomachache
• Sweating
• Swollen glands
• Unexplained weight loss
• Unusual bleeding or bruising
• Unusual weight gain
• Wheezing

• Anxiety
• Behavior changes similar to drunkenness
• Bleeding
• Blood in urine or stools
• Bluish fingernails, palms, or nailbeds
• Bruising
• Cloudy urine
• Cold sweats
• Cool pale skin
• Drowsiness
• Headache
• Large hives
• Persistent bleeding or oozing from puncture sites, mouth, or nose
• Rash
• Severe nausea
• Shakiness
• Sore mouth or tongue
• Swelling of eyelids, lips, or face
• Vomiting of blood or material that looks like coffee grounds
• White patches in mouth and/or on tongue

Get emergency help immediately if any of the following symptoms of overdose occur:

• Confusion
• Convulsions (seizures)
• Muscle weakness, severe

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Diarrhea

• Acid or sour stomach
• Back pain
• Belching
• Bloating or swelling of face, hands, lower legs, or feet
• Bone pain
• Constipation
• Flushing
• Heartburn
• Heavy nonmenstrual vaginal bleeding
• Indigestion
• Injection site pain, redness, or swelling
• Itching
• Itchy, red skin
• Joint or muscle pain
• Limb pain
• Loss of appetite
• Mental depression
• Neck pain
• Nosebleeds
• Pale skin
• Shivering chills
• Trouble sleeping or getting to sleep
• Weight gain

• Agitation
• Blisters inside the mouth
• Coughing or spitting up blood
• Earache
• Eye dryness, redness, or pain
• Loss of bowel or bladder control
• Night sweats
• Rapid, shallow breathing
• Ringing in the ears
• Small red or purple spots on skin
• Swelling of abdominal or stomach area
• Swelling or puffiness of face or eyelids
• Swollen, painful, or tender lymph glands in neck, armpit, or groin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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