Lamivudine and Zidovudine (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Chills
• Fever
• Pale skin
• Sore throat
• Unusual tiredness or weakness

• Abdominal or stomach pain (severe)
• Burning, tingling, numbness, or pain in the hands, arms, feet, or legs
• Muscle tenderness and weakness
• Nausea
• Skin rash
• Vomiting
• Yellow eyes or skin

• Blistering, peeling, or loosening of the skin
• Canker sores
• Chest discomfort or pain
• Chills
• Convulsions
• Dark urine
• Decreased appetite
• Difficulty with breathing
• Difficulty with swallowing
• Dizziness
• Faintness
• Fast, irregular, or pounding heartbeat
• Fast, shallow breathing
• Feeling of fullness
• General feeling of discomfort
• General tiredness and weakness
• Hives or welts
• Itching
• Itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
• Jerking of all extremities
• Joint or muscle pain
• Light-colored stools
• Loss of bladder control
• Muscle pain, spasms, stiffness, or cramping
• Red skin lesions often with a purple center
• Red, irritated eyes
• Redness, soreness, or itching skin
• Sensation of pins and needles
• Shortness of breath
• Sleepiness
• Sores, ulcers, or white spots in the mouth or on the lips or tongue
• Sores, welting or blisters
• Stabbing pain
• Sudden loss of consciousness
• Swelling of the feet or lower legs
• Tingling, burning, numbness, or pain in the hands, arms, feet, or legs
• Tightness in the chest
• Troubled with breathing
• Unsteadiness or awkwardness
• Wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Headache

• Abdominal or stomach pain (mild)
• Coughing
• Decreased appetite
• Diarrhea
• Dizziness
• Trouble in sleeping

• Abnormal breathing
• Blurred vision
• Body fat redistribution or accumulation
• Darkening of the skin and mucous membranes
• Dry mouth
• Fatigue
• Flushed, dry skin
• Fruit-like breath odor
• Hair loss
• Increased hunger
• Increased thirst
• Increased urination
• Sweating
• Swelling of the breasts or breast soreness in both females and males
• Swollen, painful, or tender lymph glands in the neck, armpit, or groin
• Thinning of the hair
• Troubled breathing, unexplained

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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