If you will be taking this medicine regularly for a long time:
- Your doctor should check your progress at regular visits.
- Check with your doctor at least every 4 months to make sure you need to continue taking this medicine.
If you will be taking this medicine in large doses or for a long time, do not stop taking it without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are taking before stopping completely.
Check the labels of all nonprescription (over-the-counter [OTC]) and prescription medicines you now take. If any contain aspirin or other salicylates (including bismuth subsalicylate [e.g., Pepto-Bismol]), be especially careful. Taking or using any of these medicines while taking this combination medicine containing aspirin may lead to overdose. If you have any questions about this, check with your health care professional.
This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking this medicine.
Stomach problems may be more likely to occur if you drink alcoholic beverages while being treated with this medicine, especially if you are taking the medicine in high doses or for a long time. Check with your doctor if you have any questions about this.
Too much use of this medicine together with certain other medicines may increase the chance of stomach problems. Therefore, do not regularly take this medicine together with any of the following medicines, unless directed to do so by your medical doctor or dentist:
- Acetaminophen (e.g., Tylenol)
- Diclofenac (e.g., Voltaren)
- Diflunisal (e.g., Dolobid)
- Etodolac (e.g., Lodine)
- Fenoprofen (e.g., Nalfon)
- Floctafenine (e.g., Idarac)
- Flurbiprofen (oral) (e.g., Ansaid)
- Ibuprofen (e.g., Motrin)
- Indomethacin (e.g., Indocin)
- Ketoprofen (e.g., Orudis)
- Ketorolac (e.g., Toradol)
- Meclofenamate (e.g., Meclomen)
- Mefenamic acid (e.g., Ponstel)
- Naproxen (e.g., Naprosyn)
- Phenylbutazone (e.g., Butazolidin)
- Piroxicam (e.g., Feldene)
- Sulindac (e.g., Clinoril)
- Tiaprofenic acid (e.g., Surgam)
- Tolmetin (e.g., Tolectin)
If you are taking a laxative containing cellulose, do not take it within 2 hours of taking this medicine. Taking these medicines close together may make this medicine less effective by preventing the aspirin (contained in this combination medicine) from being absorbed by your body.
For diabetic patients:
- False urine sugar test results may occur if you take 8 or more 325-mg (5-grain) doses of aspirin (contained in this combination medicine) every day for several days in a row. Smaller doses or occasional use of aspirin usually will not affect urine sugar tests. If you have any questions about this, check with your doctor, especially if your diabetes is not well controlled.
Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests, such as the metyrapone test and the phentolamine test, may be affected by this medicine.
If you plan to have surgery, including dental surgery, do not take aspirin (contained in this combination medicine) for 5 days before the surgery, unless otherwise directed by your medical doctor or dentist. Taking aspirin during this time may cause bleeding problems.
If you think you or someone else may have taken an overdose of this medicine, get emergency help at once. Taking an overdose of this medicine or taking alcohol or other CNS depressants with it may lead to unconsciousness and possibly death. Some signs of an overdose are continuing ringing or buzzing in ears; any hearing loss; severe confusion, drowsiness, or weakness; shortness of breath or slow or troubled breathing; staggering; and slow heartbeat.
This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.
Meprobamate (contained in this combination medicine) may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.