Polyethylene Glycol 3350 and Electrolytes (Oral Route)
Original Article: http://www.mayoclinic.com/health/drug-information/DR600319
US Brand Names
The polyethylene glycol (PEG) and electrolytes solution is used to clean the colon (large bowel or lower intestine) before certain tests or surgery of the colon. The PEG-electrolyte solution is usually taken by mouth. However, sometimes it is given in the hospital through a nasogastric tube (a tube inserted through the nose).
The PEG-electrolyte solution acts like a laxative. It causes liquid stools or mild diarrhea. In this way, it flushes all solid material from the colon, so the doctor can have a clear view of the colon.
The PEG-electrolyte solution is available only with your doctor's prescription.
This product is available in the following dosage forms:
- Powder for Solution
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Although there is no specific information comparing use of PEG-electrolyte solution in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Belladonna Alkaloids
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Enalapril Maleate
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Blockage or obstruction of the intestine or
- Paralytic ileus or
- Perforated bowel or
- Toxic colitis or
- Toxic megacolon—PEG-electrolyte solution may make these conditions worse; in some cases the colon may rip open or tear
Your doctor may have special instructions for you, depending on the type of test you are going to have. If you have not received such instructions or if you do not understand them, check with your doctor in advance.
Take the PEG-electrolyte solution exactly as directed . Otherwise, the test you are going to have may not work and may have to be done again.
It will take close to 3 hours to drink all of the PEG-electrolyte solution. The first bowel movement may start an hour or so after you start drinking the solution. Continue drinking all the solution to get the best results, unless otherwise directed by your doctor.
Do not eat anything for at least 3 hours before taking the PEG-electrolyte solution. If you do so, the colon may not get completely clean. If you are drinking the PEG-electrolyte solution the evening before the test, you may drink clear liquids (e.g., water, ginger ale, decaffeinated cola, decaffeinated tea, broth, gelatin) up until the time of the test. However, check first with your doctor.
For patients using the powder form of this medicine :
- The powder must be mixed with water before it is used. Add lukewarm water to the fill mark on the bottle.
- Shake well until all the ingredients are dissolved.
- Do not add any other ingredients, such as flavoring, to the solution.
- After you mix the solution, you must use it within 48 hours.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For cleaning the colon:
- For oral dosage forms (oral solution and powder for oral solution):
- Adults and teenagers—Drink one full glass (8 ounces) of the PEG-electrolyte solution rapidly every ten minutes. If you sip small amounts of the solution, it will not work as well.
- Children—The amount of PEG-electrolyte solution taken is based on body weight and must be determined by your doctor. It is usually 25 to 40 milliliters (mL) per kilogram (kg) (11.3 to 18.2 mL per pound) of body weight per hour.
- For oral dosage forms (oral solution and powder for oral solution):
Store in the refrigerator. Do not freeze.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:Rare
- Skin rash
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Abdominal or stomach cramps
- Irritation of the anus
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.