Rosiglitazone and Metformin (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Pale skin
• Troubled breathing with exertion
• Unusual bleeding or bruising
• Unusual tiredness or weakness

• Anxiety
• Blurred vision
• Chest pain or discomfort
• Chills
• Cold sweats
• Coma
• Confusion
• Cool, pale skin
• Depression
• Dilated neck veins
• Dizziness
• Extreme fatigue
• Fast heartbeat
• Headache
• Increased hunger
• Irregular breathing
• Irregular heartbeat
• Nausea
• Nervousness
• Nightmares
• Seizures
• Shakiness
• Shortness of breath
• Slurred speech
• Swelling of the face, fingers, feet, or lower legs
• Weight gain
• Wheezing

• Abdominal or stomach discomfort
• Decreased appetite
• Diarrhea
• Fast, shallow breathing
• General feeling of discomfort
• Muscle pain or cramping
• Sleepiness

• Change in vision
• Dark urine
• Decreased urine output
• Hives or welts
• Itching
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Pain or discomfort in the arms, jaw, back, or neck
• Redness of the skin
• Skin rash
• Stomach pain
• Sweating
• Vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Body aches or pain
• Cough, fever, sneezing, or sore throat
• Difficulty with breathing
• Ear congestion
• Loss of voice
• Pain or tenderness around the eyes and cheekbones
• Stuffy or runny nose
• Tightness of the chest

• Back pain
• Cold or flu-like symptoms
• Difficulty with moving
• Pain in the joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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