Tramadol and Acetaminophen (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Burning, itching, and redness of the skin
• Chest pain
• Cough
• Difficulty with swallowing
• Dizziness
• Fast heartbeat
• Hives
• Itching
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Seizures (convulsions)
• Shortness of breath
• Skin rash
• Tightness in the chest
• Unusual tiredness or weakness
• Vomiting
• Wheezing

• Blistering, peeling, or loosening of the skin
• Chills
• Diarrhea
• Difficulty with breathing
• Joint or muscle pain
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Noisy breathing
• Red skin lesions, often with a purple center
• Red, irritated eyes
• Sore throat
• Sores, ulcers, or white spots in the mouth or on the lips

Get emergency help immediately if any of the following symptoms of overdose occur:

• Abdominal or stomach pain
• Black, tarry stools
• Chest pain or discomfort
• Dark urine
• Difficulty with sleeping
• Disorientation
• Drowsiness to profound coma
• Fever
• Headache
• Irregular, fast or slow, or shallow breathing
• Lethargy
• Light-colored stools
• Lightheadedness
• Loss of appetite
• Mood or other mental changes
• Nausea
• Pale or blue lips, fingernails, or skin
• Seeing, hearing, or feeling things that are not there
• Unpleasant breath odor
• Vomiting of blood
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• Anxiety
• Belching
• Bloated or full feeling
• Constipation
• Dry mouth
• Excess air or gas in the stomach or intestines
• False or unusual sense of well-being
• Feeling of warmth
• Heartburn
• Increase in bowel movements
• Increased sweating
• Indigestion
• Loose stools
• Loss of strength or energy
• Muscle pain or weakness
• Nervousness
• Numbness or tingling of the hands, legs, and feet
• Painful or difficult urination
• Redness of the face, neck, arms, and occasionally the upper chest
• Sleepiness or unusual drowsiness
• Sleeplessness
• Soft stools
• Stomach discomfort
• Trouble with sleeping
• Unable to sleep
• Weight loss

• Abnormal thinking
• Blurred vision
• Change in vision
• Clumsiness, unsteadiness, trembling, or problems with muscle control or coordination
• Cold sweats
• Continuing ringing, buzzing, or unexplained noise in the ears
• Crying
• Decrease in the frequency or amount of urination
• Decreased awareness or responsiveness
• Decreased interest in sexual intercourse
• Depression
• Difficulty in passing urine (dribbling)
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Dysphoria
• Euphoria
• Fainting
• Fast, pounding, or irregular heartbeat or pulse
• Feeling of constant movement of self or surroundings
• Feeling unusually cold
• Headache, severe or continuing
• High or low blood pressure
• Increased muscle tone
• Involuntary muscle contractions
• Loss of memory
• Loss of sense of reality
• Loss of sexual ability, desire, drive, or performance
• Migraine headache
• Morbid dreaming
• Paranoia
• Pounding in the ears
• Problems with memory
• Quick to react or overreact emotionally
• Rapidly changing moods
• Sensation of spinning
• Severe stomach pain
• Shakiness and unsteady walk
• Shivering
• Swelling of the tongue
• Vomiting of blood or material that looks like coffee grounds

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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