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Before Using
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of amlodipine and atorvastatin combination in the pediatric population. Safety and efficacy have not been established .
Atorvastatin alone is safe to use in boys and some girls 10 to 17 years of age for treating certain types of high cholesterol.
Adolescent girls taking atorvastatin should be counseled on appropriate contraceptive methods.
Geriatric
Although appropriate studies on the relationship of age to the effects of amlodipine and atorvastatin combination have not been performed in the geriatric population, geriatrics-specific problems are not expected to limit the usefulness of amlodipine and atorvastatin combination in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution in patients receiving amlodipine and atorvastatin combination .
Pregnancy
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | X | Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit. |
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Amiodarone
- Atazanavir
- Bezafibrate
- Ciprofibrate
- Clarithromycin
- Clofibrate
- Dalfopristin
- Dantrolene
- Diltiazem
- Droperidol
- Erythromycin
- Fenofibrate
- Fentanyl
- Fluconazole
- Fusidic Acid
- Gemfibrozil
- Itraconazole
- Ketoconazole
- Mibefradil
- Nefazodone
- Niacin
- Quinupristin
- Rituximab
- Telithromycin
- Tipranavir
- Troleandomycin
- Verapamil
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acebutolol
- Aliskiren
- Alprenolol
- Amprenavir
- Atenolol
- Betaxolol
- Bevantolol
- Bisoprolol
- Black Cohosh
- Bosentan
- Bucindolol
- Carteolol
- Carvedilol
- Celiprolol
- Clopidogrel
- Colchicine
- Conivaptan
- Cyclosporine
- Dalfopristin
- Darunavir
- Digoxin
- Dilevalol
- Efavirenz
- Eltrombopag
- Esmolol
- Etravirine
- Fluconazole
- Fosamprenavir
- Fosphenytoin
- Indinavir
- Itraconazole
- Ketoconazole
- Labetalol
- Levobunolol
- Lopinavir
- Mepindolol
- Metipranolol
- Metoprolol
- Nadolol
- Nebivolol
- Nelfinavir
- Oat Bran
- Oxprenolol
- Pectin
- Penbutolol
- Phenytoin
- Pindolol
- Pioglitazone
- Propranolol
- Quinupristin
- Rifampin
- Rifapentine
- Ritonavir
- Saquinavir
- Sotalol
- St John's Wort
- Talinolol
- Tertatolol
- Timolol
- Voriconazole
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
- Grapefruit Juice
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Alcohol abuse (or history of) or
- Liver disease (or history of) or
- Liver enzymes, persistently high levels—Use of this medicine may make liver problems worse.
- Aortic stenosis, severe (abnormally narrow aorta)—Use of this medicine may increase the chance of low blood pressure.
- Congestive heart failure—There is a small chance that amlodipine may make this condition worse.
- Convulsions (seizures), not well-controlled, or
- Electrolyte or metabolic enzyme deficiencies or disorders or
- Infection, severe or
- Low blood pressure or
- Major surgery or trauma, recent or
- Myopathy (a disorder of muscle tissue or muscles)—Patients with these conditions may be at risk of developing muscle problems (causing the release of muscle pigment into the urine) that may lead to kidney failure.
- Coronary artery disease, severe, obstructive—Use of this medicine may result in other heart problems.
- Stroke, recent or
- Transient ischemic attack (TIA), recent—This medicine may increase chance of having hemorrhagic stroke (stroke caused by bleeding in the brain) .
