Clofarabine (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Abdominal pain
• Abdominal tenderness
• Area rash
• Black, tarry stools
• Bleeding gums
• Blood in the urine or stools
• Bloody nose
• Blurred vision
• Burning or stinging of the skin
• Chest pain
• Chills
• Clay-colored stools
• Cold flu-like symptoms
• Confusion
• Cough or hoarseness
• Dark urine
• Decreased urine output
• Diarrhea
• Difficult or labored breathing
• Dilated neck veins
• Dizziness
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• Facial swelling
• Fainting
• Fast, pounding, or irregular heartbeat or pulse
• Feeling of warmth
• Fever
• Flushing, redness of the skin
• Headache
• Irregular breathing
• Itching
• Itching in the genital area
• Joint pain, stiffness, or swelling
• Lightheadedness
• Loss of appetite
• Lower back or side pain
• Nausea
• Nervousness
• Pain
• Painful cold sores or blisters on the lips, nose, eyes, or genitals
• Painful or difficult urination
• Pale skin
• Pinpoint red spots on the skin
• Pounding in the ears
• Rapid, shallow breathing
• Redness of the face, neck, arms, and occasionally, upper chest
• Redness, swelling, or skin pain
• Scaling of the skin on the hands and feet
• Severe abdominal or stomach cramps with pain
• Shortness of breath
• Skin rash
• Slow or fast heartbeat
• Small red or purple spots on the skin
• Sneezing
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Stomach pain
• Sweating
• Swelling of the ankles, feet, or lower legs
• Swelling or inflammation of the mouth
• Swollen glands
• Tenderness
• Tightness in the chest
• Tingling of the hands and feet
• Troubled breathing with exertion
• Ulcers, sores, or white spots in the mouth
• Unpleasant breath odor
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Unusually warm skin
• Vomiting
• Vomiting of blood
• Warmth on the skin
• Watery and severe diarrhea, which may also be bloody
• Weight gain
• Wheezing
• Yellow eyes or skin

• Agitation
• Anxiety
• Bloating
• Blue lips and fingernails
• Chest pain or discomfort
• Cloudy urine
• Constipation
• Coughing that sometimes produces a pink frothy sputum
• Darkened urine
• Decrease or increase in the amount of urine
• Decreased level of consciousness
• Depression
• Difficult, fast, or noisy breathing, sometimes with wheezing
• Dry mouth
• General feeling of discomfort or illness
• Hives
• Hostility
• Hyperventilation
• Increased sweating
• Indigestion
• Irritability
• Muscle aches and pains
• Muscle twitching
• Pain or tenderness around the eyes and cheekbones
• Pains in the stomach, side, or abdomen, possibly radiating to the back
• Rapid weight gain
• Restlessness
• Seizures (convulsions)
• Shaking
• Shivering
• Stuffy or runny nose
• Swelling of the eyelids, face, lips, or hands
• Trouble with sleeping

• Blistering, peeling, or loosening of the skin
• Red irritated eyes
• Red skin lesions, often with a purple center

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Back pain
• Bone pain
• Bruises on the skin
• Cracked lips
• Difficulty with moving
• Difficulty with swallowing
• Discouragement
• Dry skin
• Fear
• Feeling sad or empty
• Feeling unusually cold
• Injection site pain
• Itching, pain, redness, swelling, tenderness, or warmth on the skin at the injection site
• Lack or loss of strength
• Loss of interest or pleasure
• Muscle pain or stiffness
• Pain in the limbs
• Pain in the rectum
• Right upper stomach pain and fullness
• Skin discoloration
• Sore mouth or tongue
• Swollen joints
• Tiredness
• Trouble concentrating
• Unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
• Unusually warm skin
• Weight loss
• White patches with diaper rash

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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