Clonidine and Chlorthalidone (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Difficulty in breathing
• Dizziness (extreme) or faintness
• Feeling cold
• Pinpoint pupils of eyes
• Slow heartbeat
• Unusual tiredness or weakness (extreme)

Check with your doctor as soon as possible if any of the following side effects occur:

• Dryness of mouth
• Increased thirst
• Irregular heartbeat
• Mood or mental changes
• Muscle cramps or pain
• Nausea or vomiting
• Weak pulse

• Confusion
• Convulsions (seizures)
• Decreased mental activity
• Irritability
• Muscle cramps
• Unusual tiredness or weakness

• Mental depression
• Swelling of feet and lower legs

• Black, tarry stools
• Blood in urine or stools
• Cough or hoarseness
• Fever or chills
• Joint pain
• Lower back or side pain
• Paleness or cold feeling in fingertips and toes
• Pinpoint red spots on skin
• Skin rash or hives
• Stomach pain (severe) with nausea and vomiting
• Unusual bleeding or bruising
• Vivid dreams or nightmares
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Constipation
• Dizziness
• Drowsiness
• Dryness of mouth
• Unusual tiredness or weakness

• Decreased sexual ability
• Diarrhea
• Dizziness or lightheadedness when getting up from a lying or sitting position
• Dry, itching, or burning eyes
• Increased sensitivity of skin to sunlight
• Loss of appetite
• Nausea or vomiting
• Nervousness
• Upset stomach

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

• Anxiety or tenseness
• Chest pain
• Fast or pounding heartbeat
• Headache
• Increased salivation
• Nausea
• Nervousness
• Restlessness
• Shaking or trembling of hands and fingers
• Stomach cramps
• Sweating
• Trouble in sleeping
• Vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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