Clindamycin (Oral Route, Injection Route, Intravenous Route)
Original Article: http://www.mayoclinic.com/health/drug-information/DR600453
US Brand Names
Canadian Brand Names
Clindamycin is used to treat bacterial infections. It will not work for colds, flu, or other virus infections.
Clindamycin is available only with your doctor's prescription.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
This medicine has been tested in children and, in effective doses, has not been reported to cause different side effects or problems than it does in adults.
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of clindamycin in the elderly with use in other age groups.
|All Trimesters||B||Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.|
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Kidney disease (severe) or
- Liver disease (severe)—Severe kidney or liver disease may increase blood levels of this medicine, increasing the chance of side effects
- Stomach or intestinal disease, history of (especially colitis, including colitis caused by antibiotics, or enteritis)—Patients with a history of stomach or intestinal disease may have an increased chance of side effects
For patients taking the capsule form of clindamycin:
- The capsule form of clindamycin should be taken with a full glass (8 ounces) of water or with meals to prevent irritation of the esophagus (tube between the throat and stomach).
For patients taking the oral liquid form of clindamycin:
- Use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.
- Do not use after the expiration date on the label. The medicine may not work properly after this date. Check with your pharmacist if you have any questions about this.
To help clear up your infection completely, keep taking this medicine for the full time of treatment, even if you begin to feel better after a few days. If you have a ``strep'' infection, you should keep taking this medicine for at least 10 days. This is especially important in "strep" infections. Serious heart problems could develop later if your infection is not cleared up completely. Also, if you stop taking this medicine too soon, your symptoms may return.
This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take each dose at evenly spaced times day and night. For example, if you are to take 4 doses a day, doses should be spaced about 6 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For bacterial infection:
- For oral dosage forms (capsules and solution):
- Adults and teenagers—150 to 300 milligrams (mg) every six hours.
- Infants up to 1 month of age: Use and dose must be determined by your doctor.
- Infants and children 1 month of age and older: Dose is based on body weight. The usual dose is 2 to 5 mg per kilogram (kg) (0.9 to 2.3 mg per pound) of body weight every six hours; or 2.7 to 6.7 mg per kg (1.2 to 3.0 mg per pound) of body weight every eight hours.
- For injection dosage form:
- Adults and teenagers—300 to 600 mg every six to eight hours injected into a muscle or vein; or 900 mg every eight hours injected into a muscle or vein.
- Infants up to 1 month of age: Dose is based on body weight. The usual dose is 3.75 to 5 mg per kg (1.7 to 2.3 mg per pound) of body weight every six hours injected into a muscle or vein; or 5 to 6.7 mg per kg (2.3 to 3.0 mg per pound) of body weight every eight hours injected into a muscle or vein.
- Infants and children 1 month of age and older: Dose is based on body weight. The usual dose is 3.75 to 10 mg per kg (1.7 to 4.5 mg per pound) of body weight every six hours injected into a muscle or vein; or 5 to 13.3 mg per kg (2.3 to 6.0 mg per pound) of body weight every eight hours injected into a muscle or vein.
- For oral dosage forms (capsules and solution):
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Do not refrigerate the oral liquid form of clindamycin. If chilled, the liquid may thicken and be difficult to pour. Follow the directions on the label.
It is important that your doctor check your progress at regular visits.
If your symptoms do not improve within a few days, or if they become worse, check with your doctor.
In some patients, clindamycin may cause diarrhea.
- Severe diarrhea may be a sign of a serious side effect. Do not take any diarrhea medicine without first checking with your doctor . Diarrhea medicines, such as loperamide (Imodium A-D) or diphenoxylate and atropine (Lomotil), may make your diarrhea worse or make it last longer.
- For mild diarrhea, diarrhea medicine containing attapulgite (e.g., Kaopectate tablets, Diasorb) may be taken. However, attapulgite may keep clindamycin from being absorbed into the body. Therefore, these diarrhea medicines should be taken at least 2 hours before or 3 to 4 hours after you take clindamycin by mouth.
- If you have any questions about this or if mild diarrhea continues or gets worse, check with your health care professional.
Before having surgery (including dental surgery) with a general anesthetic, tell the medical doctor or dentist in charge that you are taking clindamycin.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:More common
- Abdominal or stomach cramps and pain (severe)
- Abdominal tenderness
- Diarrhea (watery and severe), which may also be bloody
(the above side effects may also occur up to several weeks after you stop taking this medicine)Less common
- Sore throat and fever
- Skin rash, redness, and itching
- Unusual bleeding or bruising
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Diarrhea (mild)
- Nausea and vomiting
- Stomach pain
- Itching of rectal, or genital (sex organ) areas
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.