Drospirenone and Estradiol (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These may include certain types of cancer, such as leukemia or bladder cancer. Discuss these possible effects with your doctor.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Breast pain
  • Full or bloated feeling
  • Heavy nonmenstrual vaginal bleeding
  • Pressure in the stomach
  • Surgery
  • Swelling of abdominal or stomach area
Less common
  • Bloating or swelling of face, arms, hands, legs, or feet
  • Change in vaginal discharge
  • Increased clear or white vaginal discharge
  • Pain or feeling of pressure in pelvis
  • Rapid weight gain
  • Tingling of hands or feet
  • Unusual weight gain or loss
  • Vaginal bleeding
Incidence not known
  • Abdominal pain
  • Anxiety
  • Blurred vision
  • Change in vision
  • Chest pain or discomfort
  • Clear or bloody discharge from nipple
  • Confusion
  • Constipation
  • Cough
  • Coughing up blood
  • Depression
  • Difficulty in speaking
  • Dimpling of breast skin
  • Dizziness or lightheadedness
  • Double vision
  • Dry mouth
  • Fainting
  • Fast heartbeat
  • Headache
  • Headache, severe and throbbing
  • Inability to move arms, legs, or facial muscles
  • Inability to speak
  • Incoherent speech
  • Increased urination
  • Inverted nipple
  • Loss of appetite
  • Lump in breast or under the arm
  • Metallic taste
  • Muscle weakness
  • Nausea and vomiting
  • Numbness or weakness in your arm or leg, or on one side of your body
  • Pain or discomfort in arms, jaw, back, or neck
  • Pain or redness in your lower leg (calf)
  • Persistent crusting or scaling of nipple
  • Poor insight and judgment
  • Problems with memory, vision, speech, or walking
  • Redness or swelling of breast
  • Seeing double
  • Shortness of breath
  • Slow speech
  • Sore on the skin of the breast that does not heal
  • Sudden or severe headache
  • Sudden shortness of breath or troubled breathing
  • Sweating
  • Thirst
  • Trouble recognizing objects
  • Trouble thinking and planning
  • Trouble walking
  • Unusual tiredness or weakness
  • Weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Accidental injury
  • Back pain
  • Body aches or pain
  • Chills
  • Diarrhea
  • Difficulty in breathing
  • Ear congestion
  • Fever, sneezing, or sore throat
  • General feeling of discomfort or illness
  • Joint pain
  • Loss of voice
  • Muscle aches and pains
  • Nasal congestion
  • Pain in arms or legs
  • Pain or tenderness around eyes and cheekbones
  • Runny nose
  • Shivering
  • Stuffy or runny nose
  • Sweating
  • Tightness of chest or wheezing
  • Trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Precautions

DR600455

Portions of this document last updated:

Nov. 1, 2009

Source: Drug Information provided by: Micromedex

Copyright © 2009 Thomson Healthcare Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.


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