Pioglitazone and Metformin (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Bladder pain
• Bloody or cloudy urine
• Difficult, burning, or painful urination
• Frequent urge to urinate
• Lower back or side pain
• Swelling of the face, fingers, feet, or lower legs
• Weight gain

• Pain or swelling in the arms or legs without any injury
• Pale skin
• Troubled breathing with exertion
• Unusual bleeding or bruising
• Unusual tiredness or weakness

• Abdominal or stomach discomfort
• Anxiety
• Blurred vision
• Chills
• Cold sweats
• Coma
• Confusion
• Cool, pale skin
• Decreased appetite
• Depression
• Diarrhea
• Dizziness
• Fast heartbeat
• Fast, shallow breathing
• General feeling of discomfort
• Headache
• Increased hunger
• Muscle pain or cramping
• Nausea
• Nervousness
• Nightmares
• Seizures
• Shakiness
• Shortness of breath
• Sleepiness
• Slurred speech

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Body aches or pain
• Cough
• Difficulty with breathing
• Ear congestion
• Fever, sneezing, or sore throat
• Loss of voice
• Runny nose
• Stuffy nose

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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