Daptomycin (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Fever
• Rapid weight gain
• Tingling of the hands or feet
• Unusual weight gain or loss

• Abdominal or stomach pain
• Agitation
• Black, tarry stools
• Bladder pain
• Bloody or cloudy urine
• Blurred vision
• Chest pain or discomfort
• Chills
• Coma
• Confusion
• Convulsions
• Cough
• Decreased frequency or amount of urine
• Decreased urine output
• Depression
• Diarrhea
• Difficult or labored breathing
• Difficult, burning, or painful urination
• Dilated neck veins
• Dizziness
• Dry mouth
• Extreme fatigue
• Fainting
• Faintness or lightheadedness when getting up suddenly from a lying or sitting position
• Fast heartbeat
• Frequent urge to urinate
• Headache
• Hostility
• Increased blood pressure
• Increased thirst
• Irregular breathing
• Irregular heartbeat
• Irritability
• Itching in the genital or other skin areas
• Itching, pain, redness, swelling, tenderness, or warmth on the skin
• Lethargy
• Lightheadedness
• Loss of appetite
• Lower back or side pain
• Mood changes
• Muscle pain or cramps
• Muscle twitching
• Nausea
• Nervousness
• Numbness or tingling in the hands, feet, or lips
• Pale skin
• Pounding in the ears
• Rapid weight gain
• Rapid, shallow breathing
• Scaling
• Seizures
• Shortness of breath
• Slow or fast heartbeat
• Sneezing
• Sore throat
• Stupor
• Sweating
• Swelling of the face, fingers, ankles, or hands
• Tightness in the chest
• Troubled breathing with exertion
• Unusual bleeding or bruising
• Usual tiredness or weakness
• Vomiting of blood or material that looks like coffee grounds
• Weight gain
• Wheezing

• Bleeding gums
• Blood in the urine or stools
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Clay-colored stools
• Dark urine
• Difficulty with moving
• Drowsiness
• Eye pain
• Feeling of warmth
• Feeling unusually cold
• General feeling of illness
• Headache
• Hives
• Hoarseness
• Increase in bone pain
• Irritation
• Itching
• Joint pain, stiffness, or swelling
• Loss of appetite
• Mood or mental changes
• Muscle aching or cramping
• Muscle spasms (tetany) or twitching
• No blood pressure or pulse
• Pain in the joints
• Pinpoint red spots on the skin
• Rapid or irregular heartbeat
• Rash
• Redness of the face, neck, arms, and occasionally, upper chest
• Redness of the skin
• Redness, blistering, peeling, or loosening of the skin
• Shivering
• Skin rash, encrusted, scaly and oozing
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Stopping of heart
• Swelling of the eyelids, face, lips, hands, or feet
• Swollen glands
• Swollen joints
• Swollen, painful, or tender lymph glands in the neck, armpit, or groin
• Trembling
• Troubled breathing or swallowing
• Twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
• Unconsciousness
• Unpleasant breath odor
• Unusual bleeding or bruising
• Vomiting of blood
• Yellow eyes or skin

• Abdominal or stomach cramps
• Abdominal or stomach tenderness
• Diarrhea, watery and severe, which may also be bloody
• Difficulty with swallowing
• Dry cough
• Pain
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Unusual weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• Diarrhea, mild
• Difficulty having a bowel movement (stool)

• Anxiety
• Back pain
• Blurred vision
• Cold sweats
• Coma
• Cool, pale skin
• Decreased appetite
• Depression
• Flushed, dry skin
• Fruit-like breath odor
• Increased hunger
• Increased urination
• Itching of the vagina or outside genitals
• Lack or loss of strength
• Limb pain
• Nervousness
• Nightmares
• Pain during sexual intercourse
• Shakiness
• Skin rash
• Sleeplessness
• Slurred speech
• Sweating
• Thick, white, curd-like vaginal discharge without odor or with mild odor
• Trouble sleeping
• Unable to sleep
• Unexplained weight loss

• Acid or sour stomach
• Bad, unusual, or unpleasant (after) taste
• Belching
• Change in taste
• Continuing ringing or buzzing or other unexplained noise in the ears
• Excess air or gas in the stomach or intestines
• Feeling of constant movement of self or surroundings
• Full feeling
• Hearing loss
• Heartburn
• Indigestion
• Pain or discomfort in the chest, upper stomach, or throat
• Passing gas
• Pressure in the stomach
• Red, sore eyes
• Seeing, hearing, or feeling things that are not there
• Sensation of spinning
• Sore mouth or tongue
• Swelling of the abdominal or stomach area
• Swelling or inflammation of the mouth
• Weakness
• White patches in the mouth or on the tongue

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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