Cyclophosphamide (Oral Route, Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Cough or hoarseness
• Fever or chills
• Lower back or side pain
• Missing menstrual periods
• Painful or difficult urination

• Blood in the urine
• Dizziness, confusion, or agitation
• Fast heartbeat
• Joint pain
• Shortness of breath
• Swelling of the feet or lower legs
• Unusual tiredness or weakness

• Black, tarry stools
• Pinpoint red spots on the skin
• Unusual bleeding or bruising

• Frequent urination
• Redness, swelling, or pain at the injection site
• Sores in the mouth and on the lips
• Sudden shortness of breath
• Unusual thirst
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Darkening of the skin and fingernails
• Loss of appetite
• Nausea or vomiting

• Diarrhea
• Flushing or redness of the face
• Headache
• Increased sweating
• Skin rash, hives, or itching
• Stomach pain
• Swollen lips

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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