Denileukin Diftitox (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Back pain
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Blurred vision
• Body aches or pain
• Chest pain
• Confusion
• Cough
• Difficulty with breathing
• Difficulty with moving
• Difficulty with swallowing
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• Ear congestion
• Fast or irregular heartbeat
• Feeling unusually cold
• Fever or chills
• Headache
• Loss of appetite
• Loss of strength or energy
• Loss of voice
• Muscle aching or cramping
• Muscle pains or stiffness
• Nasal congestion
• Nausea
• Pain in the joints and muscles
• Rapid weight gain
• Rash
• Runny nose
• Shivering
• Shortness of breath
• Sneezing
• Sore throat
• Sweating
• Swollen joints
• Tightness in the chest
• Tingling of the hands or feet
• Unusual tiredness or weakness
• Unusual weight gain or loss
• Vomiting
• Warmth and flushing of the skin
• Wheezing

• Abdominal pain, severe
• Black, tarry stools
• Blood in the urine or stools
• Cloudy urine
• Cough or hoarseness accompanied by fever or chills
• Headache, severe
• Loss of coordination
• Lower back or side pain accompanied by fever or chills
• Pain in the groin or leg
• Painful or difficult urination accompanied by fever or chills
• Pinpoint red spots on the skin
• Slurring of speech
• Sudden vision changes
• Swelling or pain at the injection site
• Unusual bleeding or bruising
• Weakness of the arm and leg

• Dry, puffy skin
• Increased heart rate
• Weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Change in taste
• Diarrhea
• Itching
• Loss of taste

• Constipation
• Indigestion
• Numbness or tingling of the fingers, toes, or face
• Runny nose
• Trouble with sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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