Donepezil (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• Diarrhea
• Loss of appetite
• Muscle cramps
• Nausea
• Trouble in sleeping
• Unusual tiredness or weakness
• Vomiting

• Abnormal dreams
• Constipation
• Dizziness
• Drowsiness
• Fainting
• Frequent urination
• Headache
• Joint pain, stiffness, or swelling
• Mental depression
• Pain
• Unusual bleeding or bruising
• Weight loss

• Black, tarry stools
• Bloating
• Bloody or cloudy urine
• Blurred vision
• Burning, prickling, or tingling sensations
• Cataract
• Chills
• Clumsiness or unsteadiness
• Confusion
• Cough
• Decreased urination
• Difficult or painful urination
• Dryness of mouth
• Eye irritation
• Fever
• Flushing of skin
• Frequent urge to urinate
• High or low blood pressure
• Hives
• Hot flashes
• Increase in sexual desire or performance
• Increased heart rate and breathing
• Increased sweating
• Increased urge to urinate during the night
• Irregular heartbeat
• Itching
• Loss of bladder control
• Loss of bowel control
• Mood or mental changes, including abnormal crying, aggression, agitation, delusions, irritability, nervousness, or restlessness
• Nasal congestion
• Pain in chest, upper stomach, or throat
• Problems with speech
• Runny nose
• Severe thirst
• Shortness of breath
• Sneezing
• Sore throat
• Sunken eyes
• Tightness in chest
• Tremor
• Troubled breathing
• Wheezing
• Wrinkled skin

• Back, leg, or stomach pains
• Bleeding gums
• Chest pain or discomfort
• Coma
• Convulsions
• Dark urine
• Difficulty breathing
• Fast or irregular heartbeat
• Fatigue
• General body swelling
• General tiredness and weakness
• High fever
• Increased thirst
• Indigestion
• Light-colored stools
• Muscle pain or cramps
• Nausea and vomiting
• Nosebleeds
• Pains in stomach, side, or abdomen, possibly radiating to the back
• Pale skin
• Rash
• Seeing, hearing, or feeling things that are not there
• Seizures
• Severe muscle stiffness
• Severe nausea
• Slow or irregular heartbeat
• Stomach pain
• Sweating
• Swelling of face, ankles, or hands
• Tiredness
• Unusually pale skin
• Upper right abdominal or stomach pain
• Yellow eyes and skin

• Convulsions (seizures)
• Increased sweating
• Increased watering of mouth
• Increasing muscle weakness
• Low blood pressure
• Severe nausea
• Severe vomiting
• Slow heartbeat
• Troubled breathing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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