Enfuvirtide (Subcutaneous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Awkwardness
• Burning, numbness, tingling, or painful sensations or weakness in arms, hands, legs, or feet
• Cough
• Headache
• Pain or tenderness around eyes and cheekbones
• Shortness of breath or troubled breathing
• Stuffy or runny nose
• Tightness of chest
• Unsteadiness
• Wheezing

• Bloating
• Chills
• Constipation
• Darkened urine
• Dry or itching eyes
• Excessive tearing
• Eye discharge
• Fast heartbeat
• Fever
• Indigestion
• Itching, pain, redness, swelling, tenderness, or warmth on skin at injection site
• Loss of appetite
• Lump or growth on skin
• Nausea
• Pains in stomach, side, or abdomen, possibly radiating to the back
• Redness, pain, swelling of eye, eyelid, or inner lining of eyelid
• Vomiting
• Yellow eyes or skin

• Difficulty in breathing or swallowing
• Fast heartbeat
• Skin itching, rash, or redness
• Swelling of face, throat, or tongue

• Black, tarry stools
• Bleeding gums
• Blood in urine or stools
• Bloody urine
• Chest pain
• Decreased frequency or amount of urine
• Inability to move arms and legs
• Increased blood pressure
• Increased thirst
• Lower back or side pain
• Painful or difficult urination
• Pale skin
• Pinpoint red spots on skin
• Sneezing
• Sore throat
• Sudden numbness and weakness in the arms and legs
• Swelling of face, fingers, lower legs; weight gain
• Ulcers, sores, or white spots in mouth
• Unusual bleeding or bruising
• Unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Abnormal growth filled with fluid or semisolid material
• Bruising
• Burning or stinging of skin
• Decreased appetite
• Diarrhea
• Discouragement
• Dry mouth
• Fear
• Feeling sad or empty
• Flushing
• Hard lump
• Irritability
• Itching skin
• Lack of appetite
• Lack or loss of strength
• Large, flat, blue or purplish patches in the skin
• Muscle pain
• Nervousness
• Painful cold sores or blisters on lips, nose, eyes, or genitals
• Redness of skin
• Small lumps under the skin
• Tiredness
• Trouble concentrating
• Trouble sleeping
• Unusually warm skin
• Weight loss

• Bad, unusual, or unpleasant (after) taste
• Burning, itching, and pain in hairy areas
• Change in taste
• Diarrhea
• General feeling of discomfort or illness
• Joint pain
• Pus at root of hair
• Stomach pain
• Swollen, painful, or tender lymph glands in neck, armpit, or groin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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