Fulvestrant (Intramuscular Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Rapid weight gain
• Tingling of the hands or feet
• Unusual weight gain or loss

• Difficult or labored breathing
• Shortness of breath
• Tightness in the chest
• Wheezing

• Black, tarry stools
• Chest pain
• Chills
• Cough
• Fever
• Flushing or redness of the skin
• Hives or welts
• Itching
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Pain in the chest, groin, or legs, especially the calves
• Painful or difficult urination
• Severe and sudden headache
• Skin rash
• Slurred speech
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Sudden loss of coordination
• Sudden and severe weakness or numbness in the arm or leg
• Sudden unexplained shortness of breath
• Swollen glands
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Vaginal bleeding
• Vision changes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Back pain
• Bladder pain
• Bloody or cloudy urine
• Body aches or pain
• Bone pain
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Depression
• Diarrhea
• Difficulty having a bowel movement (stool)
• Difficulty with moving
• Dizziness
• Dryness or soreness of the throat
• Feeling faint, dizzy, or lightheaded
• Feeling of warmth or heat
• Feeling sad or empty
• Frequent urge to urinate
• General feeling of discomfort or illness
• Headache
• Hoarseness
• Irritability
• Joint pain
• Lack or loss of appetite
• Lack or loss of strength
• Loss of interest or pleasure
• Lower back or side pain
• Muscle aches and pains
• Muscle stiffness
• Nausea
• Pain at the injection site
• Pain in the arms or legs
• Pelvic pain
• Shivering
• Skin rash
• Stomach pain
• Sudden sweating
• Tender, swollen glands in the neck
• Trouble concentrating
• Trouble with swallowing
• Unable to sleep
• Voice changes
• Vomiting
• Weight loss

• Nervousness
• Pain, swelling, or redness in the joints
• Pale skin

• Dizziness or lightheadedness
• Feeling of constant movement of self or surroundings
• Sensation of spinning

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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