Mitotane (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Darkening of the skin
• Diarrhea
• Dizziness or lightheadedness
• Drowsiness
• Loss of appetite
• Mental depression
• Nausea or vomiting
• Skin rash
• Unusual tiredness or weakness

• Blood in the urine
• Blurred vision
• Double vision

• Shortness of breath
• Wheezing

• Chills
• Cloudy urine
• Cold sweats
• Confusion
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
• Feeling of warmth
• Fever
• Frequent urination
• Headache
• Lower abdominal cramping
• Nervousness
• Painful urination
• Pounding in the ears
• Redness of the face, neck, arms, and occasionally, upper chest
• Slow or fast heartbeat
• Vision changes
• White area over the eye

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Feeling of constant movement of self or surroundings
• Indigestion
• Passing of gas
• Sensation of spinning
• Sleepiness
• Stomach pain, fullness, or discomfort
• Unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

• Aching muscles
• Flushing or redness of the skin
• Muscle twitching

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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