Naratriptan (Oral Route)

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Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of naratriptan in the pediatric population. Safety and efficacy have not been established.

Geriatric

Use of naratriptan is not recommended in elderly patients with kidney problems, liver problems, heart and blood vessel disease, or high blood pressure.

Pregnancy

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Almotriptan
• Bromocriptine
• Dihydroergotamine
• Eletriptan
• Ergoloid Mesylates
• Ergonovine
• Ergotamine
• Frovatriptan
• Linezolid
• Methylergonovine
• Methysergide
• Rizatriptan
• Sumatriptan
• Zolmitriptan

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amitriptyline
• Citalopram
• Clovoxamine
• Desvenlafaxine
• Duloxetine
• Escitalopram
• Femoxetine
• Fluoxetine
• Fluvoxamine
• Lorcaserin
• Milnacipran
• Nefazodone
• Paroxetine
• Reboxetine
• Sertraline
• Sibutramine
• St John's Wort
• Tapentadol
• Trazodone
• Tryptophan
• Venlafaxine
• Zimeldine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Angina (chest pain) or
• Basilar migraine (migraine with vision and hearing problems) or
• Cerebrovascular disease (e.g., stroke, transient ischemic attack), or history of or
• Heart attack, history of or
• Heart or blood vessel problems or
• Hemiplegic migraine (migraine with some paralysis) or
• Hypertension (high blood pressure), uncontrolled or
• Ischemic bowel disease (bowels have low blood supply) or
• Kidney disease, severe or
• Liver disease, severe or
• Peripheral vascular disease (clogged arteries)—Should not be used in patients with these conditions.

• Coronary artery disease, history of or
• Diabetes or
• Hypercholesterolemia (high cholesterol in the blood) or
• Hypertension (high blood pressure) or
• Obesity or
• Raynaud's syndrome—Use with caution. The chance of side effects may be increased. Heart or blood vessel disease and high blood pressure sometimes do not cause any symptoms, so some people do not know that they have these problems. Before deciding whether you should use naratriptan, your doctor may need to do some tests to make sure that you do not have any of these conditions.

• Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

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