Palonosetron (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Blurred vision
• Chest pain or discomfort
• Confusion
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• Fainting
• Irregular heartbeats that continue
• Shortness of breath
• Sweating
• Unusual tiredness or weakness

• Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site
• Extra heartbeats
• Nervousness
• Pain in the shoulders, arms, jaw or neck
• Pounding in the ears
• Slow or fast heartbeat

Get emergency help immediately if any of the following symptoms of overdose occur:

• Bluish color of fingernails, lips, skin, palms, or nail beds
• Collapse
• Gasping to breathe
• Paleness of skin
• Seizures

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Difficulty having a bowel movement (stool)
• Headache

• Abdominal pain
• Acid or sour stomach
• Belching
• Bloated full feeling
• Blood in urine
• Bloody or black, tarry stools
• Burning, crawling, itching, numbness, prickling, "pins and needles" , or tingling feelings
• Change in vision
• Chills
• Continuing ringing or buzzing
• Cough
• Decrease in frequency of urination
• Decrease in urine volume
• Deep breathing
• Diarrhea
• Difficult breathing
• Difficulty in passing urine
• Drowsiness
• Dry mouth
• Excess air or gas in stomach or intestines
• Excessive sleeping
• Eye irritation
• Fear
• Feeling happy
• Feeling of warmth
• Fever
• Flushed dry skin
• Fruit-like breath odor
• General feeling of discomfort or illness
• Hearing loss
• Heartburn
• Hiccups
• Impaired vision
• Increased hunger
• Increased thirst
• Increased urination
• Indigestion
• Joint pain
• Large, flat, blue or purplish patches in the skin
• Loss of appetite
• Muscle aches and pains
• Muscle tremors
• Numbness or tingling in hands, feet, or lips
• Painful knees and ankles
• Painful urination
• Passing gas
• Raised red swellings on the skin, the buttocks, legs or ankles
• Rash
• Red, sore eyes
• Redness of the face, neck, arms and occasionally, upper chest
• Restlessness
• Runny nose
• Shivering
• Sore throat
• Stomach discomfort, upset, or pain
• Sugar in the urine
• Swelling or protruding veins
• Trembling
• Troubled breathing
• Trouble sleeping
• Unexplained noise in ears
• Unexplained weight loss
• Unusually deep sleep
• Unusually long duration of sleep
• Vein discoloration
• Weakness or heaviness of legs

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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