Pantoprazole (Intravenous Route)

Drug Information provided by: Micromedex

ARTICLE SECTIONS

US Brand Names

Protonix

Description

Pantoprazole is used to treat certain conditions in which there is too much acid in the stomach. It is used to treat gastroesophageal reflux disease (GERD), a condition in which the acid in the stomach washes back up into the esophagus. This medicine may also be used to treat Zollinger-Ellison syndrome or other conditions (such as cancer) in which the stomach produces too much acid .

Pantoprazole works by decreasing the amount of acid produced by the stomach.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

Powder for Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of pantoprazole in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of pantoprazole in the elderly .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Atazanavir
Clopidogrel
Erlotinib

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Liver disease —This condition may cause pantoprazole to build up in the body.

Zinc deficiency, or prone to—May make your condition worse.

Proper Use

It may take several days before this medicine begins to relieve stomach pain. To help relieve this pain, antacids may be taken with pantoprazole, unless your doctor has told you not to use them.

Tell your doctor if you have ever had problems with a lack of zinc in your body. Your doctor may have you take zinc supplements.

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed into one of your veins .

Precautions

It is important that your doctor check your progress at regular visits. If your condition does not improve, or if it becomes worse, check with your doctor.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common

Accumulation of pus
Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site
Changes in skin color, pain, tenderness, or swelling of foot or leg
Fever
Stomach pain
Swollen, red, tender area of infection

Incidence not known

Abdominal pain
Absence of or decrease in body movement
Blindness
Blistering, peeling, loosening of skin
Bloating of abdomen
Bloody or cloudy urine
Bloody, black, or tarry stools
Blurred vision
Chills
Constipation
Continuing ringing or buzzing or other unexplained noise in ears
Cough
Dark-colored urine
Decreased vision
Diarrhea
Difficulty in speaking
Difficulty swallowing
Dizziness or lightheadedness
Fast heartbeat
Feeling of constant movement of self or surroundings
Greatly decreased frequency of urination or amount of urine
Hearing loss
Hives
Increased watering of the mouth
Indigestion
Itching
Joint or muscle pain
Large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
Light-colored stools
Loss of appetite
Mood or mental changes
Muscle cramps or spasms
Muscle pain or stiffness
Nausea or vomiting
Pains in stomach, side, or abdomen, possibly radiating to the back
Pale skin
Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
Red skin lesions, often with a purple center
Red, irritated eyes
Sensation of spinning
Shortness of breath
Skin rash
Sore throat
Sores, ulcers, or white spots on lips or in mouth
Swelling of feet or lower legs
Swollen glands
Tightness in chest
Unexplained bleeding or bruising
Unusual tiredness or weakness
Vomiting
Wheezing
Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common