Rifabutin (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Diarrhea
• Fever
• Heartburn
• Indigestion
• Loss of appetite
• Nausea
• Skin itching and/or rash

• Sore throat
• Sour stomach
• Vomiting

• Loss of strength or energy
• Muscle pain

• Black, tarry, stools
• Bruising or purple spots on skin
• Change in taste
• Chills
• Cough
• Eye pain
• Joint pain
• Loss of vision
• Lower back or side pain
• Muscle inflammation or pain
• Pale skin
• Painful or difficult urination
• Shortness of breath
• Ulcers, sores, or white spots in mouth
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Yellow skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Abdominal pain
• Bad, unusual, or unpleasant (after) taste in mouth
• Belching
• Bloated, full feeling
• Change in taste
• Chest pain
• Excess air or gas in stomach or intestines
• Headache
• Passing gas
• Rash
• Trouble in sleeping

This medicine commonly causes reddish-orange to reddish-brown discoloration of urine, stools, saliva, skin, sputum, sweat, and tears. This side effect usually does not need medical attention. However, tears that have been discolored by this medicine may also discolor soft contact lenses (see Precautions While Using This Medicine).

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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