Rifampin (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Abdominal or stomach pain
• Agitation
• Back pain
• Bleeding gums
• Blood in the urine or stools
• Bruising
• Confusion
• Cough or hoarseness
• Coughing or vomiting blood
• Dark urine
• Darkening of the skin
• Decreased frequency or amount of urine
• Difficulty with swallowing
• Dizziness
• Fainting
• Fast heartbeat
• Fever with or without chills
• General feeling of tiredness or weakness
• Headache
• Hives
• Hostility
• Increased blood pressure
• Increased thirst
• Irritability
• Lethargy
• Light-colored stools
• Loss of appetite
• Lower back or side pain
• Mental depression
• Nausea and vomiting
• Painful or difficult urination
• Persistent bleeding or oozing from puncture sites, mouth, or nose
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Shortness of breath
• Skin itching, rash, or redness
• Sores, ulcers, or white spots on the lips or in the mouth
• Swelling of the face, ankles, fingers, hands, or lower legs
• Tightness in the chest
• Tiredness
• Troubled breathing
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Weight gain
• Wheezing
• Yellow eyes or skin

• Blistering, peeling, or loosening of the skin
• Bloating
• Bone pain
• Chest pain
• Chills
• Cold, clammy skin
• Diarrhea, watery and severe, which may also be bloody
• Difficulty with speaking
• Double vision
• Fast heartbeat
• Fast, weak pulse
• Inability to move the arms, legs, or facial muscles
• Inability to speak
• Joint or muscle pain
• Lightheadedness
• Pale skin
• Pinpoint red spots on the skin
• Red skin lesions, often with a purple center
• Red, irritated eyes
• Redness, soreness, or itching skin
• Slow speech
• Sores, welting, or blisters
• Sweating
• Swollen glands
• Unpleasant breath odor
• Unusual weight loss

Get emergency help immediately if any of the following symptoms of overdose occur:

• Blurred vision
• Convulsions (seizures)
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Fast, pounding, or irregular heartbeat or pulse
• Full feeling in the upper abdomen or stomach
• Itching
• Low blood pressure or slow pulse
• Nausea or vomiting
• Pain in the upper abdomen or stomach
• Reddish-orange to reddish-brown color of the urine, stool, saliva, sputum, sweat, and tears
• Swelling around the eyes or face
• Unconsciousness
• Unusual tiredness or weakness
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Feeling that others are watching you or controlling your behavior
• Feeling that others can hear your thoughts
• Feeling, seeing, or hearing things that are not there
• Muscular pain, tenderness, wasting, or weakness
• Severe mood or mental changes
• Unusual behavior

• Belching
• Bloated or full feeling
• Drowsiness
• Excess air or gas in the stomach or intestines
• Indigestion
• Not able to concentrate
• Pain or discomfort in the chest, upper stomach, or throat
• Weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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