Riluzole (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Blurred vision
• Difficulty with breathing
• Difficulty with moving
• Dizziness
• Excessive muscle tone
• Headache
• Increased cough
• Muscle pain or stiffness
• Muscle tension or tightness
• Nervousness
• Pain in the joints
• Pounding in the ears
• Slow or fast heartbeat

• Bladder pain
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Bloody or cloudy urine
• Bluish lips or skin
• Burning while urinating
• Changes in skin color
• Chest congestion
• Chest pain
• Chills
• Cold sweats
• Confusion
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Cough
• Cough producing mucus
• Diarrhea
• Difficult, burning, or painful urination
• Difficult or labored breathing
• Difficulty with swallowing
• Fast, pounding, or irregular heartbeat or pulse
• Fever
• Frequent urge to urinate
• General feeling of discomfort or illness
• Headache
• Increased sputum
• Loss of appetite
• Low blood pressure or pulse
• Lower back or side pain
• Muscle aches and pains
• Nausea
• Pain
• Rapid weight gain
• Runny nose
• Shivering
• Shortness of breath
• Slow breathing
• Sneezing
• Sore throat
• Sweating
• Tenderness
• Tightness in the chest
• Tingling of the hands or feet
• Trouble sleeping
• Troubled breathing
• Unconsciousness
• Unusual tiredness or weakness
• Unusual weight gain or loss
• Vomiting
• Wheezing

• Continuing sores in the mouth
• Convulsions
• Increased thirst
• Lack of coordination
• Lack of energy
• Mental depression
• Mood or mental changes
• Muscle cramps, pain, or weakness
• Pain, tenderness, bluish color, or swelling of the foot or leg
• Redness, scaling, or peeling of the skin
• Swelling of the eyelids, mouth, lips, tongue, or throat
• Swelling of the face
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Abdominal or stomach pain
• Acid or sour stomach
• Belching
• Drowsiness
• Heartburn
• Indigestion
• Lack or loss of strength
• Numbness or tingling around the mouth
• Pain or tenderness around the eyes and cheekbones
• Stomach discomfort, upset, or pain
• Weight loss

• Back or muscle pain or stiffness
• Constipation
• Cracks in the skin
• Dizziness or lightheadedness
• Dry mouth
• Excess air or gas in the stomach or intestines
• Feeling of constant movement of self or surroundings
• Full feeling
• General feeling of discomfort or illness
• Hair loss or thinning of the hair
• Irritation or soreness of the mouth
• Itching skin
• Loss of heat from the body
• Passing gas
• Sensation of spinning
• Skin rash, encrusted, scaly, and oozing
• Sleepiness or unusual drowsiness
• Sleeplessness
• Sore mouth or tongue
• Swelling or inflammation of the mouth
• Tooth problems
• Unable to sleep
• White patches in the mouth, tongue, or throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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