Sodium Thiosulfate (Intravenous Route)

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Proper Use

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form:
  • For use with cisplatin (a cancer medicine):
    • Adults and teenagers—The first dose, given just before the cancer medicine, is usually 4 grams per square meter of body surface area, injected into a vein. The second dose is started at the same time as the cancer medicine. It is usually 12 grams per square meter of body surface area, injected into a vein over a period of six hours.
  • For cyanide poisoning:
    • Adults and teenagers—The usual dose is 12.5 grams injected into a vein at a rate of 0.625 to 1.25 grams (2.5 to 5 milliliters [mL]) per minute.
    • Children—The usual dose is 412.5 milligrams (mg) per kilogram (kg) (187 mg per pound) of body weight or 7 grams per square meter of body surface area injected into a vein at a rate of 0.625 to 1.25 grams (2.5 to 5 mL) per minute.

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