Sulfasalazine (Oral Route, Rectal Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Aching of joints
• Fever
• Headache (continuing)
• Itching
• Skin rash
• Vomiting

• Aching of joints and muscles
• Back, leg, or stomach pains
• Bloody diarrhea
• Bluish fingernails, lips, or skin
• Chest pain
• Cough
• Difficult breathing
• Difficulty in swallowing
• Chills, or sore throat
• General feeling of discomfort or illness
• Loss of appetite
• Pale skin
• Redness, blistering, peeling, or loosening of skin
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Yellow eyes or skin

Check with your doctor as soon as possible if any of the following side effects occur:

• Increased sensitivity of skin to sunlight

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Abdominal or stomach pain or upset
• Diarrhea
• Loss of appetite
• Nausea

In some patients this medicine may also cause the urine or skin to become orange-yellow. This side effect does not need medical attention.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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