Temozolomide (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Check with your doctor immediately if any of the following side effects occur:

• Amnesia
• Black, tarry stools
• Blood in the urine or stools
• Convulsions (seizures)
• Cough or hoarseness
• Fever or chills
• Infection
• Lower back or side pain
• Muscle weakness or paralysis on one or both sides of the body
• Painful or difficult urination
• Pinpoint red spots on the skin
• Swelling of the feet or lower legs
• Unusual bleeding or bruising

• Blistering, peeling, or loosening of the skin
• Chest pain
• Cough
• Difficulty swallowing
• Dizziness
• Fast heartbeat
• Fever or chills
• Hives
• Itching
• Joint or muscle pain
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Shortness of breath
• Skin rash
• Sneezing
• Sore throat
• Tightness in the chest
• Troubled breathing
• Unusual tiredness or weakness
• Wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Constipation
• Headache
• Nausea and vomiting
• Unusual tiredness or weakness

• Abdominal or stomach pain
• Anxiety
• Blurred or double vision
• Breast pain (in females)
• Burning or prickling feeling on the skin
• Confusion
• Diarrhea
• Difficulty with speaking
• Dizziness
• Drowsiness
• Loss of appetite
• Loss of muscle coordination
• Mental depression
• Muscle pain
• Runny or stuffy nose
• Skin rash or itching
• Sore throat
• Trouble with sleeping
• Unusual weight gain
• Urinary incontinence or increased urge to urinate

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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