Tiotropium (Inhalation Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Arm, back, or jaw pain
• Chest pain or discomfort
• Chest tightness or heaviness
• Fast or irregular heartbeat
• Nausea
• Shortness of breath
• Sweating

• Cough
• Difficulty with swallowing
• Dizziness
• Hives
• Itching
• Painful blisters on the trunk of body
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Skin rash
• Tightness in the chest
• Unusual tiredness or weakness
• Wheezing

• Fainting
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Palpitations
• Pounding, or irregular heartbeat or pulse

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• Belching
• Bladder pain
• Bloody or cloudy urine
• Body aches or pain
• Chest pain
• Chills
• Congestion
• Cough
• Difficult, burning, or painful urination
• Difficulty with breathing
• Dry mouth
• Dryness of the throat
• Ear congestion
• Fever
• Frequent urge to urinate
• Headache
• Heartburn
• Hoarseness
• Indigestion
• Loss of voice
• Lower back or side pain
• Pain or tenderness around the eyes and cheekbones
• Runny or stuffy nose
• Sneezing
• Sore throat
• Stomach discomfort, upset, or pain
• Tender, swollen glands in the neck
• Trouble with swallowing
• Troubled breathing
• Unusual tiredness or weakness
• Voice changes

• Abdominal or stomach pain
• Bloody nose
• Blurred vision
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Canker sores
• Difficulty having a bowel movement (stool)
• Discouragement
• Feeling sad or empty
• Flushed, dry skin
• Fruit-like breath odor
• Increased hunger
• Increased thirst
• Increased urination
• Irritability
• Lack of appetite
• Large amount of cholesterol in the blood
• Leg pain
• Loss of interest or pleasure
• Muscle pain
• Nausea
• Painful or difficult urination
• Skeletal pain
• Sore mouth or tongue
• Sores, ulcers, or white spots on the lips or tongue or inside the mouth
• Sweating
• Swelling
• Swelling or inflammation of the mouth
• Tiredness
• Trouble concentrating
• Trouble sleeping
• Troubled breathing
• Unexplained weight loss
• Vomiting
• White patches in the mouth and/or on the tongue

• Bloating
• Change in vision
• Constipation
• Diarrhea
• Itching or red skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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