Trimethoprim (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Skin rash or itching

• Black, tarry stools
• Blood in urine or stools
• Bluish fingernails, lips, or skin
• Changes in facial skin color
• Chills
• Difficult breathing or shortness of breath
• Fever with or without chills
• General feeling of discomfort or illness
• Headache
• Joint or muscle pain
• Nausea
• Neck stiffness
• Pale skin
• Pinpoint red spots on skin
• Redness, blistering, burning, tenderness, peeling, or loosening of skin or mucous membranes
• Redness, swelling, or soreness of tongue
• Red skin lesions, often with a purple center
• Sore throat
• Swelling
• Thickened or scaly skin
• Unusual bleeding or bruising
• Unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Diarrhea
• Loss of appetite
• Nausea or vomiting
• Stomach cramps or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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