Leuprolide (Intramuscular Route, Subcutaneous Route, Intradermal Route, Injection Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

For adultsLess common
  • Fast or irregular heartbeat
Rare
  • Bone, muscle, or joint pain
  • Fainting
  • Fast or irregular breathing
  • Numbness or tingling of hands or feet
  • Puffiness or swelling of the eyelids or around the eyes
  • Shortness of breath
  • Skin rash, hives, and/or itching
  • Sudden, severe decrease in blood pressure and collapse
  • Tightness in chest or wheezing
  • Troubled breathing
For males only (adults)Rare
  • Pains in chest
  • Pain in groin or legs (especially in calves of legs)
Unknown
  • Altered mental status
  • Cardiovascular collapse
  • Double vision
  • Visual changes
  • Vomiting

Check with your doctor as soon as possible if any of the following side effects occur:

For females only (adults)Rare
  • Anxiety
  • Deepening of voice
  • Increased hair growth
  • Mental depression
  • Mood changes
  • Nervousness
For childrenRare
  • Body pain
  • Burning, itching, redness, or swelling at place of injection
  • Skin rash
For females only (children)—expected in first few weeksRare
  • Vaginal bleeding (continuing)
  • White vaginal discharge (continuing)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For adultsMore common
  • Sudden sweating and feelings of warmth (also called hot flashes)
Less common
  • Blurred vision
  • Bleeding, bruising, burning, itching, pain, redness, or swelling at place of injection
  • Decreased interest in sexual intercourse
  • Dizziness
  • Headache
  • Nausea
  • Swelling of feet or lower legs
  • Swelling or increased tenderness of breasts
  • Trouble in sleeping
  • Weight gain
For females only (adults)More common
  • Light, irregular vaginal bleeding
  • Stopping of menstrual periods
Less common
  • Burning, dryness, or itching of vagina
  • Pelvic pain
For males only (adults)Less common
  • Bone pain
  • Constipation
  • Decreased size of testicles
  • Inability to have or keep an erection

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Precautions

DR601525

Portions of this document last updated:

Nov. 1, 2009

Source: Drug Information provided by: Micromedex

Copyright © 2009 Thomson Healthcare Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.


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