Trastuzumab (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Dizziness
• Fever or chills
• Headache
• Muscle aches
• Nausea or vomiting
• Shortness of breath
• Skin rash
• Sore throat
• Stuffy or runny nose
• Unusual tiredness or weakness

• Bloody nose
• Cough
• Diarrhea
• Difficult or labored breathing
• Ear congestion or pain
• Fast or irregular heartbeat
• General feeling of discomfort or illness
• Head congestion
• Hoarseness or other voice changes
• Increased cough
• Joint pain
• Loss of appetite
• Nasal congestion
• Pain or tenderness around the eyes and cheekbones
• Shivering
• Sneezing
• Sweating
• Swelling of the feet or lower legs
• Tightness in the chest
• Trouble with sleeping
• Vomiting
• Wheezing

• Blue lips and fingernails
• Blurred vision
• Chest pain
• Confusion
• Cough or hoarseness, accompanied by fever or chills
• Faintness or lightheadedness when getting up suddenly from a lying or sitting position suddenly
• Itching
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, feet, or sex organs
• Lower back or side pain, accompanied by fever or chills
• Painful or difficult urination, accompanied by fever or chills
• Pale skin
• Redness of the skin
• Trouble with breathing

• Black, tarry stools
• Bloody or cloudy urine
• Sores, ulcers, or white spots in the mouth
• Unusual bleeding or bruising
• Weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Pain

• Numbness or tingling of the hands or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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