Duloxetine (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known
  • Abdominal or stomach pain
  • Area rash
  • Blindness
  • Blistering, peeling, or loosening of the skin
  • Blurred vision
  • Change in consciousness
  • Chills
  • Clay-colored stools
  • Cold sweats
  • Confusion
  • Convulsions
  • Dark urine
  • Decreased urine output
  • Decreased vision
  • Difficulty swallowing
  • Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • Eye pain
  • Fainting
  • Fast or irregular heartbeat
  • General tiredness or weakness
  • Hives or welts
  • Hives, itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
  • Increased thirst
  • Itching
  • Joint or muscle pain
  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • Light-colored stools
  • Loss of consciousness
  • Red skin lesions, often with a purple center
  • Red, irritated eyes
  • Redness of the skin
  • Shortness of breath
  • Skin rash
  • Sores, ulcers, or white spots in the mouth or on the lips
  • Swelling of the face, ankles, or hands
  • Tearing
  • Tightness in the chest
  • Unpleasant breath odor
  • Upper right stomach pain
  • Vomiting of blood
  • Wheezing
  • Yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose
  • Agitation
  • Diarrhea
  • Fever
  • Loss of bladder control
  • Muscle spasm or jerking of all extremities
  • Overactive reflexes
  • Poor coordination
  • Restlessness
  • Shivering
  • Sleepiness or unusual drowsiness
  • Sudden loss of consciousness
  • Sweating
  • Talking or acting with excitement you cannot control
  • Trembling or shaking
  • Twitching
  • Unusual tiredness or weakness
  • Vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Body aches or pain
  • Cough
  • Difficulty having a bowel movement (stool)
  • Difficulty with breathing
  • Dry mouth
  • Ear congestion
  • Frequent urination
  • Headache
  • Lack or loss of strength
  • Loss of appetite
  • Loss of voice
  • Muscle aches
  • Nausea
  • Sleepiness or unusual drowsiness
  • Sleeplessness
  • Sneezing
  • Sore throat
  • Stuffy or runny nose
  • Sweating increased
  • Trouble sleeping
  • Unable to sleep
  • Weight loss
Less common
  • Abnormal orgasm
  • Acid or sour stomach
  • Belching
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • Change in taste
  • Change or problem with discharge of semen
  • Decreased interest in sexual intercourse
  • Difficulty with moving
  • Fear
  • Feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest
  • Heartburn
  • Inability to have or keep an erection
  • Indigestion
  • Joint pain
  • Longer than usual time to ejaculation of semen
  • Loose stools
  • Loss in sexual ability, desire, drive, or performance
  • Loss of taste
  • Muscle aching or cramping
  • Muscle pains or stiffness
  • Nervousness
  • Shakiness in the legs, arms, hands, or feet
  • Stomach discomfort, upset, or pain
  • Sudden sweating
  • Swollen joints
  • Trembling or shaking of the hands or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Precautions
DR601577 Portions of this document last updated: Dec. 1, 2012

Source: Drug Information provided by: Micromedex

Copyright © 2013 Thomson Healthcare Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.

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