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Before Using
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies on the relationship of age to the effects of cyclosporine have not been performed in children receiving organ transplants. However, no pediatric-specific problems have been documented to date .
Appropriate studies have not been performed on the relationship of age to the effects of cyclosporine in children with rheumatoid arthritis or psoriasis. Safety and efficacy have not been established .
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of cyclosporine in the elderly. However, elderly patients are more likely to have high blood pressure or age-related liver, kidney, or heart problems, which may require an adjustment of dosage in patients receiving cyclosporine .
Pregnancy
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | C | Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. |
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Bosentan
- Pitavastatin
- Sitaxsentan
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Alfalfa
- Aliskiren
- Black Cohosh
- Caspofungin
- Cerivastatin
- Colchicine
- Cyclophosphamide
- Efavirenz
- Etoposide
- Etravirine
- Felodipine
- Itraconazole
- Lanreotide
- Lovastatin
- Nafcillin
- Octreotide
- Orlistat
- Posaconazole
- Pyrazinamide
- Red Yeast Rice
- Rifabutin
- Rifampin
- Rosuvastatin
- Silodosin
- Simvastatin
- St John's Wort
- Sulfinpyrazone
- Tacrolimus
- Topotecan
- Voriconazole
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aceclofenac
- Acemetacin
- Acetazolamide
- Alclofenac
- Allopurinol
- Amiodarone
- Amphotericin B
- Amphotericin B Cholesteryl Sulfate Complex
- Amphotericin B Lipid Complex
- Amphotericin B Liposome
- Amprenavir
- Apazone
- Atorvastatin
- Azathioprine
- Benoxaprofen
- Bromfenac
- Bromocriptine
- Bufexamac
- Carprofen
- Chloramphenicol
- Chloroquine
- Cimetidine
- Ciprofloxacin
- Cisapride
- Clarithromycin
- Clindamycin
- Clometacin
- Clonidine
- Clonixin
- Dalfopristin
- Danazol
- Dexketoprofen
- Diclofenac
- Diflunisal
- Digoxin
- Diltiazem
- Dipyrone
- Dirithromycin
- Doxorubicin
- Droxicam
- Erythromycin
- Ethinyl Estradiol
- Etodolac
- Etofenamate
- Etonogestrel
- Ezetimibe
- Famotidine
- Felbinac
- Fenbufen
- Fenoprofen
- Fentiazac
- Floctafenine
- Fluconazole
- Flufenamic Acid
- Flurbiprofen
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- Glipizide
- Glyburide
- Ibuprofen
- Imipenem
- Indinavir
- Indomethacin
- Indoprofen
- Isoxicam
- Josamycin
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lornoxicam
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Melphalan
- Mestranol
- Methotrexate
- Methylprednisolone
- Metoclopramide
- Metronidazole
- Mibefradil
- Miokamycin
- Modafinil
- Morphine
- Morphine Sulfate Liposome
- Mycophenolate Mofetil
- Nabumetone
- Naproxen
- Nefazodone
- Nelfinavir
- Nevirapine
- Nicardipine
- Niflumic Acid
- Nimesulide
- Norelgestromin
- Norethindrone
- Norfloxacin
- Norgestrel
- Oxaprozin
- Oxyphenbutazone
- Phenylbutazone
- Phenytoin
- Pirazolac
- Piroxicam
- Pirprofen
- Pravastatin
- Probucol
- Propafenone
- Propyphenazone
- Proquazone
- Quinine
- Quinupristin
- Repaglinide
- Rifapentine
- Ritonavir
- Saquinavir
- Sirolimus
- Sulfadiazine
- Sulfasalazine
- Sulindac
- Suprofen
- Telithromycin
- Tenidap
- Tenoxicam
- Terbinafine
- Tiaprofenic Acid
- Tobramycin
- Tolmetin
- Tolterodine
- Troglitazone
- Verapamil
- Warfarin
- Zomepirac
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
- Grapefruit Juice
- Pomelo Juice
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Cancer or
- Hyperkalemia (too much potassium in the blood) or
- Hyperuricemia (too much uric acid in the blood) or
- Precancerous skin changes or
- Seizures (convulsions)—Cyclosporine can make these conditions worse .
- Chickenpox (including recent exposure) or
- Herpes zoster (shingles)—Risk of severe disease affecting other parts of the body.
- High blood pressure—Cyclosporine can cause high blood pressure. Patients with high blood pressure who have psoriasis or rheumatoid arthritis should not receive cyclosporine.
- Infection—Cyclosporine decreases the body's ability to fight infection.
- Intestine problems—Effects may be decreased because cyclosporine cannot be absorbed into the body.
- Kidney disease—Cyclosporine can have harmful effects on the kidney when it is taken for long periods of time. Patients with psoriasis or rheumatoid arthritis who have kidney disease should not receive cyclosporine.
- Liver disease—Effects of cyclosporine may be increased because of slower removal of the medicine from the body.
