Bortezomib (Intravenous Route, Subcutaneous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Black, tarry stools
• Bleeding gums
• Blood in the urine or stools
• Blurred vision
• Body aches or pain
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Chest pain
• Chills
• Confusion
• Cough
• Cough producing mucus
• Decreased urination
• Difficult or labored breathing
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Dry mouth
• Ear congestion
• Fainting
• Fever
• Headache
• Increase in heart rate
• Loss of voice
• Lower back or side pain
• Nerve pain
• Painful blisters on the trunk of the body
• Painful or difficult urination
• Pale skin
• Pinpoint red spots on the skin
• Rapid breathing
• Runny nose
• Shortness of breath
• Sneezing
• Sore throat
• Stuffy nose
• Sunken eyes
• Sweating
• Swollen glands
• Thirst
• Tightness in the chest
• Troubled breathing with exertion
• Ulcers, sores, or white spots in the mouth
• Unsteadiness or awkwardness
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Weakness in the arms, hands, legs, or feet
• Wheezing
• Wrinkled skin

• Decreased urine output
• Dilated neck veins
• General feeling of discomfort or illness
• Increased sensitivity to pain
• Increased sensitivity to touch
• Irregular breathing
• Irregular heartbeat
• Swelling of the face, fingers, feet, or lower legs
• Thickening of bronchial secretions
• Tingling in the hands and feet
• Troubled breathing
• Unsteadiness or awkwardness
• Weight gain

• Abdominal or stomach pain and tenderness
• Agitation
• Back pain
• Blistering, peeling, or loosening of the skin
• Bloating
• Bruising
• Change in consciousness
• Coma
• Coughing or vomiting blood
• Dark urine
• Deafness
• Deep or fast breathing with dizziness, numbness to feet, hands, and around the mouth
• Diarrhea
• Drowsiness
• Fast heartbeat
• Fear or nervousness
• General tiredness and weakness
• Hallucinations
• Irritability
• Itching
• Light-colored stools
• Loss of consciousness
• Mood or mental changes
• Pains in the stomach, side, or abdomen, possibly radiating to the back
• Persistent bleeding or oozing from puncture sites, mouth, or nose
• Pounding, slow heartbeat
• Rectal bleeding
• Red skin lesions, often with a purple center
• Red, irritated eyes
• Restlessness
• Seeing, hearing, or feeling things that are not there
• Seizures
• Shaking
• Stiff neck
• Trouble sleeping
• Upper right abdominal or stomach pain
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• Belching
• Bone pain
• Constipation
• Difficulty having a bowel movement
• Difficulty with moving
• Feeling unusually cold or shivering
• General feeling of discomfort or illness
• Heartburn
• Indigestion
• Itching skin
• Loss of appetite
• Loss of taste
• Mental depression
• Muscle cramps
• Muscle pain or stiffness
• Nausea
• Pain in the joints
• Pain in the limb
• Rash
• Sleeplessness
• Stomach discomfort or upset, or pain
• Swelling
• Swollen joints
• Unable to sleep
• Vomiting
• Weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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