Alemtuzumab (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Black, tarry stools
• Blood in urine
• Chills
• Cough
• Diarrhea
• Dizziness
• Faintness, or light-headedness when getting up from a lying or sitting position suddenly
• Fast heartbeat
• Fever
• Headache
• Itching, hives, or rash
• Nausea and vomiting
• Painful or difficult urination
• Pale skin
• Shortness of breath
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Sweating
• Swollen glands
• Tightness in the chest
• Troubled breathing, exertional
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Wheezing

• Bloating or swelling of the face, hands, lower legs, and/or feet
• Chest pain
• Hoarseness
• Lower back or side pain
• Muscle weakness
• Palpitations
• Pounding, or irregular heartbeat or pulse
• Rapid weight gain
• Rash
• Red or purple spots on the skin, varying in size and remaining after pushing the skin surface

• Flushing of the face or neck
• Swelling of the eyelids, face, or lips
• White patches on the tongue, in the mouth, or in folds of the skin, including the genitals

• Back pain
• Blindness
• Blurred vision
• Chest discomfort or pain
• Confusion
• Convulsions
• Decreased urine output
• Decreased vision
• Dilated neck veins
• Drowsiness
• Extreme fatigue
• Eye pain
• Feeling of discomfort
• Inability to move the arms and legs
• Inflammation of the joints
• Irregular breathing
• Joint pain, stiffness, or swelling
• Muscle aches or pain
• Numbness, pain, tingling, or weakness
• Painful glands
• Spitting up blood
• Sudden numbness and weakness in the arms and legs
• Swelling of the face, fingers, feet, or lower legs

Get emergency help immediately if any of the following symptoms of overdose occur:

• Inability to urinate

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Fear, nervousness
• Sleeplessness
• Trouble sleeping
• Unable to sleep

• Acid or sour stomach
• Belching
• Bone pain
• Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
• Heartburn
• Indigestion
• Lack or loss of strength
• Loss of appetite
• Painful cold sores or blisters on the lips, nose, eyes, or genitals
• Stomach discomfort, upset, or pain
• Swelling or inflammation of the mouth
• Weight loss

• Bloody nose
• Constipation
• Mood or mental changes
• Sensation of temperature change
• Sleepiness
• Stuffy nose
• Tremor
• Unexplained nosebleeds

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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