Doxorubicin Hydrochloride Liposome (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• Black, tarry stools
• Blistering, peeling, redness, and/or swelling of palms of hands or bottoms of feet
• Blood in urine or stools
• Chills
• Cough or hoarseness
• Facial swelling
• Fever
• Headache
• Loss of strength and energy
• Low blood pressure
• Lower back or side pain
• Numbness, pain, tingling, or unusual sensations in palms of hands or bottoms of feet
• Painful or difficult urination
• Pinpoint red spots on skin
• Shortness of breath
• Sore throat
• Sores in mouth and on lips
• Unusual bleeding or bruising
• Unusual tiredness or weakness

• Skin rash or itching

• Chest pain
• Decreased urine output
• Dilated neck veins
• Extreme fatigue
• Irregular breathing
• Irregular heartbeat
• Shortness of breath
• Swelling of face, fingers, feet, or lower legs
• Tightness in chest
• Troubled breathing
• Weight gain
• Wheezing
• Yellowing of the eyes and skin

• Cough
• Fever
• Pain at place of injection
• Troubled breathing
• Wheezing

• Blurred or loss of vision
• Eye pain
• Flushed, dry skin
• Frequent urination
• Fruit-like breath odor
• Unusual thirst

• Bloating or swelling of face, hands, lower legs, and/or feet
• Chest pain
• Cough or hoarseness
• Decreased urination
• Fever or chills
• Lower back or side pain
• Painful or difficult urination
• Rapid weight gain

• Cough
• Difficulty swallowing
• Hives
• Pain at place of injection
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Shortness of breath
• Tightness in chest
• Wheezing

• Black, tarry stools
• Blood in urine or stools
• Cough or hoarseness accompanied by fever or chills
• Fever or chills
• Lower back or side pain accompanied by fever or chills
• Painful or difficult urination accompanied by fever or chills
• Pinpoint red spots on skin
• Sores in mouth and on lips
• Unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Diarrhea
• Nausea
• Vomiting

• Back pain
• Difficulty swallowing
• Dizziness

• Creamy white, curd-like patches in mouth or throat
• Pain when eating or swallowing

• Constipation
• Headache

• Abdominal or stomach pain
• Changes in the lining of the mouth or nose
• Constipation
• Headache
• Loss of appetite
• Pain
• Rash
• Sore throat
• Tingling, burning, or prickly sensations

• Anxiety
• Bad, unusual, or unpleasant (after)taste
• Burning, dry, or itching eyes
• Change in taste
• Difficulty swallowing
• Excessive tearing
• Itching skin
• Muscle aches
• Redness, pain, swelling of eye, eyelid, or inner lining of eyelid
• Trouble sleeping

• Change in sense of smell
• Chills
• Clumsiness, unsteadiness, trembling, or other problems with muscle control or coordination
• Cough
• Fever
• General feeling of discomfort or illness
• Increased white vaginal discharge
• Joint pain
• Nausea
• Shakiness and unsteady walk
• Shivering
• Sore throat
• Sweating
• Thinking abnormal
• Vomiting

Liposomal doxorubicin causes the urine to turn reddish in color, which may stain clothes. This is not blood. It is to be expected and only lasts for 1 or 2 days after each dose is given.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Dry skin

• Change in skin color

This medicine often causes a temporary and total loss of hair. After treatment with liposomal doxorubicin has ended, normal hair growth should return.

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

• Fast or irregular heartbeat
• Shortness of breath
• Swelling of feet and lower legs

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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