Letrozole (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Bone fracture
• Breast pain
• Chest pain
• Chills, fever, or flu-like symptoms
• Mental depression
• Shortness of breath
• Swelling of the feet or lower legs

• Continuing or severe nervousness
• Cough
• Dizziness or lightheadedness
• Fainting
• Fast heartbeat
• Heart attack
• Increased sweating
• Nausea
• Pain in the chest, groin, or legs, especially the calves
• Severe and sudden, unexplained shortness of breath
• Severe, sudden headache
• Slurred speech
• Sudden loss of coordination
• Sudden, severe weakness or numbness in the arm or leg
• Vaginal bleeding
• Vision changes

• Black, tarry stools
• Blindness
• Blurred vision
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Chest discomfort
• Decreased vision
• Dilated neck veins
• Extreme fatigue
• Increased need to urinate
• Irregular breathing
• Irregular heartbeat
• Painful or difficult urination
• Passing urine more often
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Swollen glands
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Weight gain
• Wheezing
• White or brownish vaginal discharge

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Back pain
• Bone pain
• Hot flashes (sudden sweating and feeling of warmth)
• Joint pain
• Muscle pain

• Anxiety
• Confusion
• Constipation
• Diarrhea
• Dry mouth
• Headache
• Increased thirst
• Loss of appetite or weight loss
• Metallic taste
• Skin rash or itching
• Sleepiness
• Spinning or whirling sensation causing loss of balance
• Stomach pain or upset
• Trouble sleeping
• Vomiting
• Weakness

• Bad, unusual, or unpleasant (after) taste and thirst
• Being forgetful
• Change in taste
• Dryness of the skin
• Hair loss
• Hives or welts
• Increased appetite
• Irritability
• Nervousness
• Red, sore eyes
• Redness of the skin
• Swelling or inflammation of the mouth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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